BACKGROUND The economic impact of therapeutic non-adherence in chronic diseases has rarely been examined using qualitative standards for economic evaluation. This study illustrates the impact of non-adherence on the cost utility of renal transplantation versus haemodialysis from the societal perspective and examines the scope for adherence-enhancing interventions. METHODS Long-term costs and ...

OBJECTIVE To explore how a group of Swedish general practitioners (GPs) manage patients with a sore throat in relation to current guidelines as expressed in interviews. DESIGN Qualitative content analysis was used to analyse semi-structured interviews. SETTING Swedish primary care. SUBJECTS A strategic sample of 25 GPs. MAIN OUTCOME MEASURES Perceived management of sore throat patients....

Abstract Introduction The prevalence of obstructive sleep apnea (OSA) is high in patients with systolic heart failure (HFrEF) and has been associated poor prognosis this patient population. impact positive airway pressure (PAP) therapy OSA HFrEF remains unclear. This retrospective study sought to investigate the association between 1-year adherence PAP healthcare resource utilization (HCRU) new...

Prothrombinase complex assembly, in real time, on platelets adherent to immobilized von Willebrand Factor (vWf) was examined by total internal reflection fluorescence spectroscopy (TIRFS). Electron microscopy showed that the platelets adhered to vWf in a largely unactivated state and could be activated by thrombin. Antibody binding to glycoprotein (GP) Ib and functional GPIIb-IIIa receptor mole...

Abstract Introduction Previous studies have shown that treatment of obstructive sleep apnea (OSA) with positive airway pressure (PAP) therapy in patients OSA and comorbid depression may improve response to antidepressant medication therapy. At the same time, scant evidence has examined impact PAP adherence depression. Patients adhere one be more likely other therapies or healthy behaviors a so-...

It is well known in the economic literature that labour supply curve can bend backwards and, therefore, leisure be a Giffen good. also normal This article proves if good, it has to result that, contrary common knowledge economics, not all goods, are inferior goods. These results could taken into account, for example, when finding empirical evidence and designing policies on supply, an era of ma...

Cells with monocyte/macrophage lineage expressing receptor activator of NF-κB (RANK) differentiate into osteoclasts following stimulation with the RANK ligand (RANKL). Cell adhesion signaling is also required for osteoclast differentiation from precursors. However, details of the mechanism by which cell adhesion signals induce osteoclast differentiation have not been fully elucidated. To invest...