نتایج جستجو برای: adenoviruses

تعداد نتایج: 6905  

Journal: :Human gene therapy 2007
Tanja Hakkarainen Merja Särkioja Petri Lehenkari Susanna Miettinen Timo Ylikomi Riitta Suuronen Renee A Desmond Anna Kanerva Akseli Hemminki

Systemic adenoviral delivery into tumors is inefficient because of liver sequestration of intravenously administered virus. One potential solution for improving bioavailability is the use of carrier cells such as human mesenchymal stem cells (MSCs), which have been suggested to have inherent tumor tropism. Here we investigated the capacity of capsid-modified adenoviruses to infect and replicate...

2016
Sook-Young Lee Jeong-Hoon Kim Tae-Kun Seo Jin Sun No Hankyeom Kim Won-keun Kim Han-Gu Choi Sung-Ho Kang Jin-Won Song

Antarctica is considered a relatively uncontaminated region with regard to the infectious diseases because of its extreme environment, and isolated geography. For the genetic characterization and molecular epidemiology of the newly found penguin adenovirus in Antarctica, entire genome sequencing and annual survey of penguin adenovirus were conducted. The entire genome sequences of penguin adeno...

Journal: :Journal of virology 2007
Andrea Hesse Daniela Kosmides Roland E Kontermann Dirk M Nettelbeck

Recombinant adenoviruses have emerged as promising agents in therapeutic gene transfer, genetic vaccination, and viral oncolysis. Therapeutic applications of adenoviruses, however, would benefit substantially from targeted virus cell entry, for example, into cancer or immune cells, as opposed to the broad tropism that adenoviruses naturally possess. Such tropism modification of adenoviruses req...

Journal: :Applied and environmental microbiology 2005
Nena Nwachuku Charles P Gerba Amy Oswald Faezeh D Mashadi

The results of this study confirm that adenoviruses are the most resistant enteric viruses to inactivation by UV light and that adenovirus 40 appears to be the most resistant. The effect of freeze-thawing and storage in water may affect the sensitivity of some adenoviruses to inactivation by UV light.

2017
Marc Garcia-Moure Naiara Martinez-Vélez Ana Patiño-García Marta M. Alonso

Osteosarcoma is the most common bone cancer among those with non-hematological origin and affects mainly pediatric patients. In the last 50 years, refinements in surgical procedures, as well as the introduction of aggressive neoadjuvant and adjuvant chemotherapeutic cocktails, have increased to nearly 70% the survival rate of these patients. Despite the initial therapeutic progress the fight ag...

Journal: :Journal of virology 2006
Gary S Shapiro Crystal Van Peursem David A Ornelles Jerome Schaack James DeGregori

Despite the utility of recombinant adenoviral vectors in basic research, their therapeutic promise remains unfulfilled. Most engineered adenoviral vectors use a heterologous promoter to transcribe a foreign gene. We show that adenoviruses containing the cytomegalovirus immediate-early promoter induce the expression of the proapoptotic cellular protein TAp73 via the cyclin-dependent kinase-retin...

Journal: :Journal of clinical microbiology 1979
G W Gary J C Hierholzer R E Black

Virus particles morphologically resembling adenovirus were found in fecal specimens from infants and were examined for cultivability with standard cell culture techniques and for characteristics of human adenoviruses. Specimens from 13 of 15 infants could not be cultivated in cell cultures. The two adenoviruses that were cultivated, types 1 and 31, reacted in the expected manner in all tests. C...

Journal: :Annals of African medicine 2007
M Aminu A A Ahmad J U Umoh M C de Beer M D Esona A D Steele

BACKGROUND Adenoviruses, particularly enteric adenoviruses (EAds) type 40 (Ad40) and type 41(Ad41), can cause acute and severe diarrhea in young children worldwide. This study was conducted to delineate the epidemiological features of adenoviruses identified in children with gastroenteritis in Northwestern Nigeria. METHODS All 282 specimens comprising 248 diarrheic and 34 non-diarrheic stools...

2015
Consuelo Rubio-Guerri Daniel García-Párraga Elvira Nieto-Pelegrín Mar Melero Teresa Álvaro Mónica Valls Jose Luis Crespo Jose Manuel Sánchez-Vizcaíno

BACKGROUND Adenoviruses are common pathogens in vertebrates, including humans. In marine mammals, adenovirus has been associated with fatal hepatitis in sea lions. However, only in rare cases have adenoviruses been detected in cetaceans, where no clear correlation was found between presence of the virus and disease status. CASE PRESENTATION A novel adenovirus was identified in four captive bo...

Journal: :Avian diseases 1976
D G Simmons J G Gray

Several turkey respiratory adenoviruses were isolated in turkey embryonic liver cells from nasal turbinate filtrate collected from clinically ill turkey poults during postmortem examination. Suspect adenovirus inoculum had to remain in cell culture for 5 to 7 days, and 9 blind passages were required before a sample was declared negative. Once isolated, the turkey adenoviruses adapted rapidly to...

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