BACKGROUND Biopsy and polypectomy frequently are performed for lesions that carry a low risk of malignant transformation in the colon. Elastic scattering spectroscopy (ESS) is a novel optical biopsy technique that can distinguish, almost instantaneously, between normal and abnormal tissue in vivo, without the need to remove tissue. We assessed the diagnostic potential of ESS in the colon to dif...

Aim: to reveal hereditary mutations in patients with adenomatous polyps of the gastrointestinal tract. Patients and methods: a retrospective cohort study included 8 tract (ranging from 4 several hundred). The APC, AXIN2, BMPR1A, BRCA2, CDH1, CHEK2, EPCAM, GALNT12, GREM1, MLH1, MLH3, MSH2, MSH3, MSH6, MutYH, NTHL1, PMS2, POLD1, POLE, SMAD4, STK11 genes were studied using new generation sequencin...

Background: In western countries with high prevalence of colorectal cancers, colonic polyps are usually adenomatous. There are few studies from Iran regarding to the predominant type of polyps in colorectal area. Objectives: We conducted this retrospective study to evaluate the predominant colorectal polyps in our center as the largest referral center of the South region of Iran. Material and M...

Purpose: The rate of gastrointestinal adenomatous polyps, often regarded as precancerous lesions, developing into cancer is 40 – 70 %. Endoscopic resection has been the preferred method for treating gastric polyps since late 1960s. Surgical removal continues to play an important role in treatment polyps; however, efficacy such cannot be guaranteed, and may recur.Case presentation: Here, we repo...

We describe 2 extended kindreds supposedly manifesting familial multiple adenomatous polyposis coli (FPC), but which show marked heterogeneity in the phenotypic expression of colorectal adenomatous polyps. In one family, 2 individuals had diffuse polyposis at very early ages (7 and 10 years), while 6 others (aged 23 to 72 years) had solitary polyps only. Of the patients with solitary polyps, 2 ...

Fundic gland polyps (FGPs) are the most common type of gastric polyps (up to 50%). They are found in up to 0.8-1.9 % of the general population, and in 40-84 % of the patients suffering from familial polyposis syndromes. They might be sporadic or associated to polyposis syndromes. When the former, they should be considered exclusively benign lesions, and possibly related to the chronic use of pr...

Familial adenomatous polyposis (FAP) is a rare syndrome characterized by the presence of hundreds to thousands of colorectal adenomas and is responsible for less than 1% of all colorectal cancers. The syndrome is also characterized by extra-colorectal features including amongst others upper gastrointestinal tract polyps and desmoid tumors. The syndrome is inherited by an autosomal dominant gene...

the United States. A family history of colon cancer is a strong risk factor for development of the disease. Dietary factors have also been associated with the development of colorectal cancer. This article reviews the epidemiology, pathogenesis, genetics, clinical presentation, staging, and treatment of colorectal cancer. Surgical and adjuvant therapies for both colonic and rectal cancers are d...

background: the association between adenomatous polyps and malignancy has an important role in patient screening and follow up after polypectomy. due to less attraction towards the segmental resection, colonoscopic evaluation of malignancy has found its utmost importance role. polyp size and morphology have dictated the potential of malignancy in prior studies, however, in recent decade some au...

BACKGROUND This study was aimed at identifying the prevalence, distribution, and clinicopathologic characteristic of colonic polyps among Nigerians undergoing colonoscopy at the Obafemi Awolowo University Teaching Hospitals complex, Ile-Ife, Nigeria. We also determined the polyp detection rate (PDR), polyps per colonoscopy (PPC) and adenoma detection rate (ADR). MATERIALS AND METHODS This is ...