نتایج جستجو برای: adeabc
تعداد نتایج: 71 فیلتر نتایج به سال:
Acinetobacter baumannii is a common causative agent of hospital-acquired infections and a leading cause of infection in burns patients. Carbapenem-resistant A. baumannii is considered a major public-health threat and has been identified by the World Health Organization as the top priority organism requiring new antimicrobials. The most common mechanism for carbapenem resistance in A. baumannii ...
Bacterial two-component regulatory systems (TCSs) facilitate changes in gene expression in response to environmental stimuli. TCS BaeR regulons influence tigecycline susceptibility in Acinetobacter baumannii through positively regulating the pump genes adeA and adeB. In this study, we demonstrate that an additional two transport systems, AdeIJK and MacAB-TolC, are also regulated by BaeSR. In th...
The present study was designed to analyze the difference of the adeB gene expression levels under conditions of induced resistance and to verify the significance of the AdeABC efflux pump in the in vitro induction of Acinetobacter baumannii (A. baumannii). Strains were isolated from blood or drainage samples in the First Hospital of China Medical University. The minimum inhibitory concentration...
after launch, 61% of the tigecycline prescriptions were ’off label’, especially for patients with ventilator-associated pneumonia (VAP) due to MDR Acinetobacter spp. (D. Curcio, F. Fernández and F. Duret, unpublished data). The high concentration in alveolar cells (77.5-fold higher than serum), the increase in carbapenem-resistant Acinetobacter spp. in Argentina (54%), the lack of medical evide...
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