The Work Ability Index (WAI) is a well-accepted questionnaire designed to assess an individual’s work ability. However, most research with WAI has focused on occupational populations with physical demands at work. The purpose of this study is to explore the value of WAI as screening instrument among professionals in a Dutch university. Based on database data about absenteeism, questionnaire dat...

The Work Ability Index (WAI) is a well-accepted questionnaire designed to assess an individual’s work ability. However, most research with WAI has focused on occupational populations with physical demands at work. The purpose of this study is to explore the value of WAI as screening instrument among professionals in a Dutch university. Based on database data about absenteeism, questionnaire dat...

The Work Ability Index (WAI) is a well-accepted questionnaire designed to assess an individual’s work ability. However, most research with WAI has focused on occupational populations with physical demands at work. The purpose of this study is to explore the value of WAI as screening instrument among professionals in a Dutch university. Based on database data about absenteeism, questionnaire dat...

A widely held viewpoint in the field of predictive biomarkers for disease holds that no single marker can provide high enough discrimination and that a panel of markers, combined in some type of algorithm, will be needed. Motivated by a recent study where 27 additional markers for ovarian cancer, many of which had good predictive value alone, failed to substantially increase the predictive abil...

In the field of posttraumatic stress disorder (PTSD), the revisions to the DSM-IV definition of a potentially traumatic event are contentious. Proponents praise the subjective emphasis, while others contend that the changes to the criterion broadened the conceptualization of PTSD. This study examined the predictive utility of Criterion A events, examining the stressor (A1) and subjective emotio...

Businesses that rely on a value-added network to provide information processing and communications services are only as secure as the network itself. The customer should understand the types of processing and control services provided by such vendors, and the potential exposures that use of these networks can entail. This article describes the control issues that must be addressed, the controls...

A number of studies have been conducted to investigate the predictive value of common genetic variants for complex diseases. To date, these studies have generally shown that common variants have no appreciable added predictive value over classical risk factors. New sequencing technology has enhanced the ability to identify rare variants that may have larger functional effects than common varian...

BACKGROUND The incremental prognostic value of myocardial perfusion-gated single photon emission computed tomography (MPGS) compared with exercise test has not yet been properly evaluated. METHODS AND RESULTS Five thousand six hundred seventy-two consecutive patients with known or suspected coronary disease undergoing exercise MPGS between 1997 and 2007 were included. Three-year predictive mo...

Hundreds of 'molecular signatures' have been proposed in the literature to predict patient outcome in clinical settings from high-dimensional data, many of which eventually failed to get validated. Validation of such molecular research findings is thus becoming an increasingly important branch of clinical bioinformatics. Moreover, in practice well-known clinical predictors are often already ava...