We used a series of adamantane derivatives to probe the structure of the phencyclidine locus in either the resting or desensitized state of the nicotinic acetylcholine receptor (AChR). Competitive radioligand binding and photolabeling experiments using well-characterized noncompetitive antagonists such as the phencyclidine analogue [piperidyl-3,4-(3)H(N)]-N-[1-(2-thienyl)cyclohexyl]-3,4-piperid...

BACKGROUND Adamantanes resistance in H3N2 viruses has been increasing since 2000, and in 2005-2006 reached nearly 100% in most countries, with the circulation of the N-lineage. In 2006-2007, however, a significant decrease in resistance was observed in many regions. OBJECTIVES To explore potential links between adamantane resistance and the A(H3N2) viruses that circulated between 2006 and 200...

The crystal structure of the title adamantane derivative, C(12)H(18)O(3), has been determined by X-ray diffraction. The structure is stabilized by inter-molecular O-H⋯O hydrogen bonds, forming a chain.

The asymmetric unit of the title compound, C(18)H(22)N(2), contains two independent mol-ecules which differ slightly with respect to the torsion angles involving the atoms joining the adamantyl and benzimidazole groups. The bond angles in the adamantane cage vary within the range 108.27 (9)-110.55 (10)°. The benzimidazole ring system in both mol-ecules is essentially planar, the maximum deviati...

The title compound, C(15)H(19)NO(4), contains one crystallographically independent mol-ecule in the asymmetric unit. The N-O-C-O torsion angle is 1.97 (9)°. The two pairs of vicinal H atoms that lie above or below the plane defined by the five-membered pyrrolidine-2,5-dione ring are an average of 6.57 (5)° from being eclipsed. The average absolute C-C-C-C torsion angle in the adamantane skeleto...

The synthesis and single-molecule imaging of two inherently fluorescent nanocars equipped with adamantane wheels is reported. The nanocars were imaged using 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) as the chromophore, which was rigidly incorporated into the nanocar chassis via Sonogashira cross-coupling chemistry that permitted the synthesis of nanocars having different geometries. I...

A new approach towards the rapid identification of quality binders to cucurbiturils--those that combine high affinity with high selectivity for a particular homologue--was developed. The assay exploits macrocycle-specific optical fingerprints (colorimetric or fluorimetric) of carefully selected indicators dyes. The screening of a guest library revealed known (e.g., adamantane derivatives) and n...

Chemical oxidation of a Mo(3)S(7) cluster featuring catecholate ligands, namely [Mo(3)S(7)(Cl(4)cat)(3)](2-) (Cl(4)cat = tetrachlorocatecholate), allows the isolation of a unique nanoscopic molecular cage made of four iodide-bridged Mo(3)S(7) clusters as the kinetically favoured product.

BACKGROUND M2 proton channel of H1N1 influenza A virus is the target protein of anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The NMR structure of the M2 channel protein determined by Schnell and Chou (Nature, 2008, 451, 591-595) may help people to solve the drug-r...