BACKGROUND Several anti-viral drugs have demonstrated efficacy in preventing Cytomegalovirus (CMV) infections in solid organ transplant (SOT) patients. The recently approved valganciclovir is the most commonly used and most expensive drug for CMV prevention. The safety and efficacy data have been drawn from a single trial. We hypothesized that valganciclovir may not be as safe as nor more effec...

Purpose: To report a case of ocular and facial herpes zoster meningitis after vaccination.Case summary: A 60-year-old man was administered Zostavax® on his left arm; he developed vesicular rash over eye forehead 4 days afterwards. He started antiviral drugs for the rash, visited hospital severe headache spread to involve tip nose, face, palate by day 7. taking Synthyroid® (Bukwang Pharmaceutica...

New, simple and sensitive spectrophotometric methods for the determination of acyclovir and ganciclovirhave been developed. The method is based on the oxidation of 2, 4-dinitrophenyl hydrazine (2, 4 DNP) and coupling of the oxidized product with acyclovir and ganciclovirto give intensely coloredchromogen. Acyclovir and ganciclovirshowed maximum absorbance at 414 nm and 450 nm with linearity was...

Steroid use is a considerable risk in recurring Herpes Simplex Virus (HSV) epithelial keratitis. This case demonstrates the efficacy of treatment with oral acyclovir followed by a maintenance dose to reduce the risk of recurrences. I. Case History a. 77yo Caucasian male b. CC: Blurry vision at distance and near OS c. Ocular Hx: (+) Corneal ulcer OS, (+) HSV epithelial keratitis OS 12/1998, 5/20...

The ability of herpes simplex virus type 1 (HSV-1) DNA polymerase, HeLa polymerase alpha, and HeLa polymerase beta to utilize several dGTP analogues has been investigated using a defined synthetic template primer. The relative efficiencies of the triphosphates of 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir triphosphate, ACVTP), 9-[(1,3-dihydroxy-2-propoxy)methyl] guanine (ganciclovir triphosp...

The organic anion transporters 1 and 3 (OAT1 and OAT3) and organic cation transporter 2 (OCT2) are important for renal tubular drug secretion. In contrast, evidence for OAT2 expression in the human kidney is limited, and its role in renal drug transport is unknown. Both mRNA (real-time polymerase chain reaction) and protein (Western blotting) for OAT2 were detected in renal cortex from eight do...

BACKGROUND Cytomegalovirus (CMV), the most common opportunistic viral infection in solid organ transplant recipients, is associated with substantial morbidity and mortality. PURPOSE To assess the efficacy of universal prophylaxis and preemptive approaches in preventing CMV organ disease and other complications in solid organ transplant recipients. DATA SOURCES Using no language restrictions...

The organic anion transporters 1 and 3 (OAT1 and OAT3), and organic cation transporter 2 (OCT2) are important for renal tubular drug secretion. In contrast, evidence for OAT2 expression in the human kidney is limited, and its role in renal drug transport is unknown. Both mRNA (real-time polymerase chain reaction) and protein (Western blotting) for OAT2 was detected in renal cortex from eight do...

Cytomegalovirus (CMV) is one of the most frequent microbes linked with kidney transplant recipients. CMV infection typically classified as virus isolation in any body fluid or specimen. We present a 43-year-old man who underwent deceased donor donor-seronegative and recipient-seronegative (CMV D-/R-) status completed three months prophylaxis high-dose acyclovir given his low-risk status. He was...

In the early days of heart transplantation, cytomegalovirus (CMV) disease was frequent and often severe. The development of strategies to prevent CMV disease has had a major beneficial effect [1, 2], but problems still remain. Traditionally, patients with donor-seropositive (D+)/recip-ient-seronegative (RϪ) status have had the highest risk of high viral loads, tissue-invasive disease, and ganci...