In this work, the dissolution-absorption studies were conducted on marketed tablets of acyclovir (ACIVIR-200mg) and the mucoadhesive tablets of acyclovir using varying concentration of sodium lauryl sulfate as a permeation enhancer. The purpose of this study was to improve the absorption of acyclovir using sodium lauryl sulfate as permeation enhancer. The everted and perfused intestine model wa...

It has been reported that conjugating acyclovir, a potent antiviral with low oral bioavailability, to L-valine increases its urinary excretion in rats. However, it was also reported that this increase is not found for the D-valine ester, suggesting that a carrier-mediated mechanism is involved in its intestinal absorption. Therefore, mechanisms involved in the transepithelial transport of L-val...

OBJECTIVE Acyclovir prophylaxis has been considered as mandatory for patients receiving bortezomib because herpes zoster is a common adverse event associated with the use of bortezomib. Although the minimal effective dose of acyclovir for prophylaxis has not yet established, the efficacy of low-dose acyclovir prophylaxis, 400 mg once daily, has been suggested. METHODS We retrospectively revie...

objective: in recent years, antiviral drugs have been used widely in the glob to prevent and treat viral diseases. they injected into eggs to eliminate pathogens and prevent of egg transmission of disease, but the adverse effects of drugs have always been a major concern. there is little information available about the safety of antiviral drugs in the embryonated eggs of birds. the objective of...

Objective: In recent years, antiviral drugs have been used widely in the glob to prevent and treat viral diseases. They injected into eggs to eliminate pathogens and prevent of egg transmission of disease, but the adverse effects of drugs have always been a major concern. There is little information available about the safety of antiviral drugs in the embryonated eggs of birds. The objective of...

Objective: In recent years, antiviral drugs have been used widely in the glob to prevent and treat viral diseases. They injected into eggs to eliminate pathogens and prevent of egg transmission of disease, but the adverse effects of drugs have always been a major concern. There is little information available about the safety of antiviral drugs in the embryonated eggs of birds. The objective of...

A double blind, placebo controlled trial of 5% acyclovir cream, applied topically five times a day for five days, was carried out in 49 patients with recurrent herpes labialis. These patients had a total of 74 episodes, 34 of which were treated with the 5% acyclovir cream and 40 with matching placebo. First episodes and all episodes treated with acyclovir cream had significantly shorter times t...

Acyclovir-resistant clinical isolates of herpes simplex virus type 1 (HSV-1) were analyzed in vitro for their susceptibilities to essential oils of ginger, thyme, hyssop, and sandalwood. All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 clinical isolates and reduced plaque formation significantly.

Acyclovir treatment of acute herpes zoster speeds rash healing and decreases pain and ocular complications. The limited oral bioavailability of acyclovir necessitates frequent dosing. Valaciclovir, the l-valyl ester of acyclovir, is rapidly and almost completely converted to acyclovir in vivo and gives three- to fivefold increases in acyclovir bioavailability. In a randomized, double-blind, mul...