introduction acute lymphoblastic leukemia (all) is the most common malignancy of childhood. patients with all commonly present with easy bruising and infections due to medullary involvement. the extra medullary involvements of all manifests as hepatosplenomegaly, lymphadenopathy, and testicular enlargement. among extramedullary manifestations of the all, thyroid involvement is rare. herein, we ...

abstract background: fatigue is the most common side effect of chemotherapy in children with acute lymphoblastic leukemia (all).acupressure is one of the most popular non‑pharmacologic methods used to reduce fatigue in other settings. the aim of the study was to evaluate the effect of acupressure on reducing fatigue among children with all compared with a placebo treatment. materials and method...

Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizi...

background obesity is a medical problem in survivors of childhood acute lymphoblastic leukemia. obesity is associated with many complications, so it is important to investigate the respective etiology. leptin is a protein synthesized in the fatty tissue and is effective in the control of obesity. survey of leptin in acute lymphoblastic leukemia (all) survivors could be helpful in controlling ob...

acute myeloid leukemia (aml-m7) is a type of pediatric aml accounting for 3–10% of primary childhood aml and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions. we report a rare case of aml .a 26-month-old boy who presented with weakness and fatigue. he was diagnosed as a case of amlm-7...

background: dysregulation of wnt signaling has been reported in many malignancies. objective: this study was conducted to investigate the expression pattern of 14 members of the wnt gene family in different immunophenotypic subtypes of all. methods: semi-quantitative rt-pcr was performed on samples from 71 all patients and 36 age-matched healthy individuals. the all patients were categorized in...

background: acute myeloid leukemia (aml) is known as one of the most common leukemia among adults. environmental and different genetic factors affect disease process, prognosis and treatment. among different genetic factors npm1, flt3, mll and baalc genes are the most effective on patient's survival rate. the aim of this study was to assess amount of baalc gene expression in aml patients, and i...

background: the treatment of acute promyelocy!c leukemia with all-trans-re!noic acid (atra) some!mes results in a syndrome characterized by fever, respiratory distress, weight gain, pleural or pericardial effusion, and pulmonary infiltrates. we report the major clinical and radiologic features of atra syndrome. materials and methods: in the past, occasional case reports and literature pertainin...

t cell acute lymphoblastic leukemia (all) is an invasive disease with a higher incidence in children and adolescents. in terms of immunophenotype, t-all is positive for cd2, cd7, cd34 and hla-dr, and the level of these markers is increased with increasing age. in addition, the myeloid markers (cd13, cd33) are sometimes expressed in t-all. in this study, we introduce a rare case of a 28-year-old...

a retrospective study was done on 130 aml patients treated in shariati and imam hospitals in tehran from 1991 to 1997 to investigate the value of three post-remission methods of treatment. all patients who were in complete remission (cr) (group i) had been treated with ara-c (300 mg/m2/day continuous infusion for 5 days) and daunorubicine (45 mg/m2/day for 3 days) as induction and early consoli...