1 Acute Rosiglitazone Treatment is Cardioprotective against Ischemia/Reperfusion Injury by 1 Modulating AMPK, Akt, and JNK Signaling in Non-diabetic Mice 2 3 4 Alex Morrison, Xiaoyan Yan, Chao Tong, Ji Li 5 6 Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, 7 University at Buffalo-SUNY, Buffalo, NY 8 9 10 11 Running title: Cardioprotective effects of acute ...

We have begun assessing the toxicology of commercially available fluorescent semiconductor nanocrystals that contain toxic metals. We have found that: 1) Fluorescence of the aquatic invertebrate Cerodaphnia dubia increased significantly after a 4 hr exposure to 200 ppt nanocrystals. Changes in fluorescence were time and dose dependent. 2) 48-h acute toxicology endpoint assessment of these nanoc...

3.1. SCOPE AND LIMITATIONS The acute, subchronic, and chronic toxicology of the chlorinated dioxins, dibenzofurans, biphenyls, and related compounds have been reviewed extensively in recent years. This chapter summarizes knowledge on the toxicology of tetrachlorodibenzo-p-dioxin (TCDD), but also includes references to other dioxin-like compounds when relevant data are available. Included are se...

Objective: The present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of Crocus sativus L. (saffron) using mice in two different regimens of acute and sub-acute administration. Material and Methods: In acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

objective: the present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of crocus sativus l. (saffron) using mice in two different regimens of acute and sub-acute administration. material and methods: in acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evalute the acute and subchronic toxicology of chloral hydrate in the random-bred CD-1 mouse, to provide data for risk assessment. The acute oral LD50 of this compound was 1442 and 1265 mg/kg in male and female mice, respectively. Acute toxicity appeared to be related t...

Overt response to a single 6.25 mg dose of ochratoxin A (OTA) by oral gavage to 15 months male rats was progressive loss of weight during the following four days. Lost weight was restored within one month and animals had a normal life-span without OTA-related terminal disease. Decline in plasma OTA concentration only commenced four days after dosing, while urinary excretion of OTA and ochratoxi...

Acute Toxicity and Sub-Lethal Effects of Non-Point Source Pollutants on Invertebrates by Jocelyn Ann Romano University Program in Integrated Toxicology Nicholas School of the Environment and Earth Sciences Duke University Date:_______________________ Approved: ___________________________ Dan Rittschof, Co-Chair ___________________________ Patricia McClellan-Green, Co-Chair _____________________...

conclusions this study demonstrates that the mental states associated with specific diseases should not be ignored in evaluating health states. although there are benefits to relying on expert panels and the general population in evaluating various health states, attention to the particular health states of the patients (taking into account their associated mental well-being) should also be uti...

medical toxicology is somehow a neglected field of medicine. support for this discipline is necessary as there are many competing interests within a nation's public health priorities (1). in the previous issue of the asia pacific journal of medical toxicology, the essentials of the empowerment of medical toxicology in the asia pacific region have been discussed (2). perhaps, there is now an urg...