Arsenic trioxide inhibits growth and promotes apoptosis in many different cancer cell lines. The National Cancer Institute is working cooperatively with research centers across the U.S. to evaluate its clinical activity in hematologic malignancies, such as acute promyelocytic leukemia, acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, non-Hodgkin's lymphoma, Hodg...

By Alvin M. Mauer I T IS TRULY gratifying to review the progress that has been made in the therapy of the acute leukemias since the introduction of aminopterin by Farber and coworkers’ in the late I 940s. This progress can be measured by the increasing proportion of patients who have achieved complete remission, the increasing duration of their survival, and the increasing evidence that for som...

introduction: heterochromatin consists of dna sequences that are not transcribed, and are repeated in short tandem at heterochromatic regions of chromosomes 1, 9, 16 as well as the distal part of long arm of chromosome y. slightly large tandem repeats at the centromeres of human chromosomes are also considered as heterochromatin regions. the main aim of the present study is to evaluate the hete...

The phenomenon of premature chromosome condensation (PCC) was used to compare the bone marrow proliferation characteristics of 163 patients with various forms of leukemia prior to the initiation of new therapy. The proliferative potential index (PPI, or fraction of G1 cells in late G1 phase) and the fraction of cells in S phase was determined and compared to the type of disease and the bone mar...

BACKGROUND Morphology and cytochemistry are the foundation for classification of leukemias in dogs and cats. Advances in automated hematology instrumentation, immunophenotyping, cytogenetics, and molecular biology are significantly improving our ability to recognize and classify spontaneous myeloproliferative and lymphoproliferative disorders. OBJECTIVE The purpose of this study was to assess...

The Philadelphia chromosome is present in more than 95% of chronic myeloid leukemia patients and 13% of acute lymphocytic leukemia patients. The Philadelphia translocation, t(9;22), fuses the BCR and ABL genes resulting in the expression of leukemia-specific, chimeric BCR-ABL messenger RNAs. To facilitate diagnosis of these leukemias, we have developed a method of amplifying and detecting only ...

Environmental Health Perspectives • volume 119 | number 11 | November 2011 A 469 and does not alter our conclusion that this meta-analysis provides support for an association between occupational exposure to benzene and increased risk of multiple myeloma, acute lymphocytic leukemia, and chronic lymphocytic leukemia (Vlaanderen et al. 2011). The authors declare they have no actual or potential c...

Background:Leukemia is cancer of blood and bone marrow cells. In general, there are four types of leukemia: chronic myelogenous leukemia (CML), acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL).  Fractal geometry can be introduced as one of the effective ways to detect this type of cancer. In this study, with introduc...

BACKGROUND Advances in treatment of acute lymphocytic leukemia increased the likelihood of developing late treatment-associated effects, such as abdominal adiposity, increasing the risk of cardiovascular disease in this population. Cranial radiotherapy is one of the factors that might be involved in this process. The aim of this study was to determine the effect of cranial radiotherapy on adipo...

Natural killer cell activity was evaluated in children with acute lymphocytic and acute myelogenous leukemia. Peripheral blood mononuclear cells isolated at the time of diagnosis and before initiation of therapy were mixed with 51Cr-labeled K562 or MOLT-4 target cells at a ratio of 100:1. In 13 consecutive cases of acute lymphocytic leukemia, the mean percentage of lysis of K562 cells (15.0%) w...