High-dose ionizing irradiations can cause acute tissue and organ damage, especially severe cutaneous lesions. These cutaneous injuries often result in further complications and incur high mortality. Therefore, it is critical to develop effective therapeutic approaches for acute high-dose ionizing irradiation injury. Intracellular reactive oxygen species (ROS) have been implicated in mediating i...

Extensive documentation has validated the role of UV irradiation as a tumor initiator and promoter, inducing both squamous and basal cell carcinomas. Human epidermis is a tissue which undergoes active metabolism of arachidonic acid to prostaglandins which is regulated by the action of prostaglandin H synthase (also known as cyclooxygenase). One mechanism for the promotional activity of UV light...

Thoracic radiotherapy is an effective treatment for many types of cancer; however it also associated with increased risk developing cardiovascular disease (CVD), appearing mainly ?10 years after radiation exposure. The present study investigated acute and early term physiological molecular changes in the system ionizing Female male ApoE?/? mice received a single exposure low or high ...

BACKGROUND The present study was performed to determine the effect of amifostine in the prevention of radiation-induced acute and late period morphologic damages in rat kidney via light and electron microscopic examinations. MATERIALS AND METHODS Control rats (n=6) received saline solution 30 min before sham irradiation; the radiotherapy alone group (n=12) received saline solution 30 min befo...

Glycosaminoglycans are important structural components in the skin and exist as various proteoglycan forms, except hyaluronic acid. Heparan sulfate (HS), one of the glycosaminoglycans, is composed of repeated disaccharide units, which are glucuronic acids linked to an N-acetyl-glucosamine or its sulfated forms. To investigate acute ultraviolet (UV)-induced changes of HS and HS proteoglycans (HS...

Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from...

The aim of the investigation was to reveal changes in neurons cerebral cortex depending on dose γ-irradiation, rate exposure, mode exposure (acute and chronic) establish priority each influencing factors (γ-irradiation, recovery time their joint impact) end result. Material methods . experiment, compliance with rules bioethics, carried out 300 adult white rats that were exposed acute chronic γ-...

Proliferation activity of bone marrow ECIB may alter feedback mechanisms of cells was studied in six patients with growth control within the leukemic acute myeloid leukemia treated by extratissue, resulting in an increased proliferacorporeal irradiation of the blood (ECIB). five fraction. It is suggested that the nonOne patient with acute lymphoblastic proliferative leukemic blast cell is not a...

Radiation pneumonitis (RP) is the most significant complication of acute treatment-related toxicities in lung cancer. Intensity-modulated radiotherapy (IMRT) with inverse planning enables us to achieve the desired dose distribution. However, there are many high-risk procedures associated with lung irradiation, including chemotherapy and surgery. We report a case of fatal treatment-related pneum...