Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a ...

Sir, Acute generalized exanthematous pustulosis (AGEP) designates an uncommon, cutaneous reaction characterized by an acute eruption of numerous, small, mostly non-follicular sterile pustules arising on a widespread oedematous erythema; fever above 38 C̊; blood neutrophil count above 7610/l and spontaneous resolution of pustules within 15 days. Typical histopathological findings are subcorneal a...

Maria V. Campanón-Toro1, Omar Sierra1, Esther Moreno1,2,3, Miriam Sobrino-García1, Maria T. Gracia-Bara1,2 and Ignacio Dávila1,2,3 1Allergy Department, University Hospital of Salamanca, 37007 Salamanca Spain, 2 IBSAL (Instituto Biosanitario de Salamanca), University Hospital of Salamanca, Spain, and 3Department of Biomedical and Diagnostic Sciences, Salamanca Medical School, University of Salam...

BACKGROUND A wide range of diseases or reactions can cause pustular eruptions of the skin. In this spectrum there seems to be a subgroup with characteristic clinical features and a typical course which is mostly caused by drugs for which the term acute generalized exanthematous pustulosis (AGEP) has been established. OBJECTIVE To describe the clinical features of AGEP. METHODS The authors' ...

Acute generalized exanthematous pustulosis is a skin reaction characterized by an acute onset, fever, and a cutaneous eruption with non-follicular sterile pustules on edematous erythema. It mimics many of the features of pustular psoriasis but is differentiated by its characteristic clinical course and history. The cause is usually ingested drugs. We report a case of acute generalized exanthema...

Differentiating between acute generalised exanthematous pustulosis (AGEP) and generalised pustular psoriasis (GPP) is very challenging because of clinical and histopathological similarities. A 60-year-old woman presented with pustular eruption and fever. She had taken dapsone and zaltoprofen for five days. Laboratory findings revealed neutrophil dominant leucocytosis and histopathological findi...

BACKGROUND Acute generalized exanthematous pustulosis (AGEP) represents a severe, acute, pustular skin reaction that is most often induced by drugs. AGEP can be difficult to differentiate from generalized pustular psoriasis (GPP) both clinically and histopathologically. We present a systematic description of the histopathological spectrum of AGEP and GPP with a focus on discriminating features....

Background. Acute generalized exanthematous pustulosis (AGEP) is an acute pustular eruption characterized by widespread nonfollicular sterile pustules. The aim of this study is to characterize the etiology, clinical features, laboratory findings, management, and outcome of patients with AGEP in Asians. Patient/Methods. A retrospective analysis was performed on patient who presented with AGEP be...

Introduction: While drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is known to be associated facial swelling, this edema can challenging identify. This study evaluates the utility of a physical examination finding, oblique earlobe crease, support diagnosis DRESS. Design: retrospective case-control in which dermatologists evaluated for presence an crease patients diagnose...