What is Antimycin? Antimycin is the active ingredient in Fintrol, a commercial piscicide. Antimycin is a mixture of closely related molecules produced by Streptomyces bacteria. Antimycin A1 was first isolated during the 1940’s, and its molecular structure determined a few years later. Antimycin (used to refer to all of the antimycin variants collectively) is an antibiotic that was found to be a...

Several factors limit the efficacy of nematicides. Consequently, modifications can be made to their active ingredient, formulation, and application to increase their efficacy.

the purpose of this study is to investigate the performance and efficiency of moringa seeds from different sources on turbidity. a protein analysis test was done for each source; then two different methods of extraction were compared to examine the coagulation activity for the moringa's active ingredient. the results of sodium chloride (naci) extraction in comparison to distilled water ext...

OBJECTIVES The objective of this study was to evaluate the intended and unintended impact on pharmaceutical use and sales of three public reimbursement reforms applied to the prescription of statins: a Spanish generic reference pricing system, and two competing policies introduced by the Andalusian Public Health Service. METHODS This study is designed as an interrupted time series analysis wi...

OBJECTIVES Given use of uterotonics for postpartum haemorrhage and other obstetric indications, the importance of potent uterotonics is indisputable. This study evaluated access to and potency of injectable uterotonics in Ghana. DESIGN Study design involved research assistants simulating clients to purchase oxytocin and ergometrine from different sources. Drug potency was measured via chemica...

A calcium shellac (CS) matrix was used to encapsulate polymeric melamine formaldehyde microcapsules (A) or CaCO3 nanoparticles-stabilized microcapsules (B), both of which encapsulated an oilbased active ingredient, producing A-CS or B-CS composite microcapsules. The mechanical properties and oil release profiles of the composite microcapsules were evaluated. The composite microcapsules showed e...

A survey of the multi-stable isotopic composition of an active pharmaceutical ingredient (API), naproxen, was performed to assess the potential of Isotope Ratio Mass Spectrometry (IRMS) to distinguish the provenance of APIs. Twenty-six lots of naproxen from six manufacturers representing four countries (Italy, India, Ireland, and the USA) were analyzed for three isotope ratios (13C/12C, 18O/16O...

Five years ago, we reported the identification and characterization of several regulatory T-cell epitopes (now called Tregitopes) that were discovered in the heavy and light chains of IgG (De Groot et al. Blood, 2008). When added ex vivo to human PBMCs, these Tregitopes activated regulatory T cells (Tregs), increased expression of the transcription factor FoxP3, and induced IL-10 expression in ...

Having validated analysis methods for medicinal ingredients is attractive for pharmaceutical companies. When a new molecule is introduced to the market, there is not any pharmacopeial analysis method for that. After publishing official methods, correlation between validated in-house methods and the official one could stablish the value of the in-house method. Sitagliptin phosphate is a new anti...

Preliminary trials suggest that the delivery system or unit described may prove to be a highly selective and effective system for delivering drugs or chemicals to coyotes. The goose egg-size unit's selectivity and effectiveness relies heavily on a newly developed synthetic olfactory coyote lure based on trimethylammonium decanoate (TMAD). The coyote is attracted to the unit, which is placed at ...