نتایج جستجو برای: activating mutation
تعداد نتایج: 342144 فیلتر نتایج به سال:
Journal:
:Nature
2014
Journal:
:New England Journal of Medicine
2008
Journal:
:Nature Genetics
2014
Journal:
:New England Journal of Medicine
2018
Journal:
:Kidney International
1998
Journal:
:Head and Neck Pathology
2016
Journal:
:Leukemia
2018
Journal:
:Anticancer research
2010
Vitali Sviatoha
Edneia Tani
Mehran Ghaderi
Regina Kleina
Lambert Skoog
BACKGROUND metastatic melanomas are incurable by systemic treatment and it is therefore of the highest concern to develop new therapeutic regimens. RAF kinases play a key role in the RAS-RAF-MAPK signalling pathway which mediates cellular response to growth signals. An inhibitor of the RAS-RAF-MAPK cascade, sorafenib, has shown promising therapeutic results in treatment of several types of meta...
Journal:
:Pediatric Rheumatology
2015
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