Proteinase-activated receptors (PARs) are a four-member family of G protein-coupled defined by their irreversible proteolytic mechanism activation. PARs have emerged as important regulators various physiological responses and implicated in numerous pathological conditions. Importantly, PAR1 PAR4 critical platelet function, while PAR2 is well established driver inflammatory responses. PAR-target...

Introduction: The neuroprotective role of opioid morphine against 6-hydroxydopamineinduced cell death has been demonstrated. However, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified. Methods: Here, we investigated the effects of different opioid agonists on 6-OHDA-induced neurotoxicity in human neuroblastoma...

Protease signaling in cells elicits multiple physiologically important responses via protease-activated receptors (PARs). There are 4 members of this family of G-protein-coupled receptors (PAR1-4). PARs are activated by proteolysis of the N terminus to reveal a tethered ligand. The rate-limiting step of PAR signaling is determined by the efficiency of proteolysis of the N terminus, which is reg...

It has been shown that activated T-cells produce and release both IL-2 and IL- 2 receptors (lL-2R). The rate of IL-2 release is proportional to its cell surface expression and state of cell activation. To clarify the molecular basis of this immunological aberration, we analysed the amount of soluble IL-2R(SIL2-R) by an ELISA technique in 68 patients with Behcet's disease (BD), 28 patient co...