نتایج جستجو برای: action to extension guidances
تعداد نتایج: 10720374 فیلتر نتایج به سال:
The use of cell cultures in research and in regenerative medicine programs has increased in the past few years, and control of the risks inherent to these procedures should be increased. People who work in stem cell bank installations should be aware of the risks implied in their work and take necessary self-protection measures for the known and unidentified risks. Work in stem cell bank instal...
Current regulatory guidances do not address specific study designs for in vitro and in vivo drug-drug interaction studies. There is a common desire by regulatory authorities and by industry sponsors to harmonize approaches, to allow for a better assessment of the significance of findings across different studies and drugs. There is also a growing consensus for the standardization of cytochrome ...
Definitive plasma protein binding (PB) studies in drug development are routinely conducted with radiolabeled material, where the radiochemical purity limits quantitative PB measurement. Recent and emerging regulatory guidances increasingly expect quantitative determination of the fraction unbound (Fu) for key decision making. In the present study, PB of 11 structurally- and therapeutically-dive...
The joint bilateral filter, which enables feature-preserving signal smoothing according to the structural information from a guidance, has been applied for various tasks in geometry processing. Existing methods either rely on a static guidance that may be inconsistent with the input and lead to unsatisfactory results, or a dynamic guidance that is automatically updated but sensitive to noises a...
We present a method to generate effective confirmation and guidance using concept-level confidence measures (CM) derived from speech recognizer output in order to handle speech recognition errors. We define two conceptlevel CM, which are on content-words and on semanticattributes, using 10-best outputs of the speech recognizer and parsing with phrase-level grammars. Content-word CM is useful fo...
Our research goal is to facilitate the sharing of stories with digital maps. The main technical novelty of this paper is a method for semi-automated creation of photo slideshows with geotagged photographs. Story authoring software like movie editors and slideshow editors enable us to create stories by arranging elements like movie clips, audio clips, photographs, etc. in the order of the storyl...
Patellar tendon moment arm length (PTma) changes at different knee flexion angles have not been determined in invivo studies. We aimed to determine PTma in four different knee angles using Magnetic Resonance Imaging (MRI) topredict in vivo changes in the moment arm length from different knee angles during running.PTma was measured as the perpendicular distance from muscle–tend...
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