Introduction: Apremilast, an oral phosphodiesterase-4 inhibitor, decreases the production of pro-inflammatory cytokines including tumour necrosis factor-α, interleukin-12/23, IL-12, IL-2, and interferon-γ; while upregulating anti-inflammatory cytokine IL-10. Its pan-immunomodulatory nature has led to its use in managing various immune-mediated dermatoses for non-FDA-approved indications. Object...

Prurigo nodularis (PN) is an eruption of lichenified or excoriated nodules related to intractable pruritus. A few reports have shown that a 308-nm excimer lamp/laser (EL) is effective for intractable PN. Herein, we report on two cases of intractable prurigo nodularis successfully treated with a new EL equipped with a filter to cut wavelengths shorter than 297 nm. Because this newly developed EL...

A 79-year-old gentleman presented with a 1-year history of many pruritic nodules on the trunk and extremities. Some blisters developed for several weeks before he visited our clinic. On physical examination, there were about 60 discrete, hyperkeratotic, brownish nodules on the trunk and four limbs (Fig. 1). Besides, there were several tense blisters right on some of the prurigo lesions and the ...

INTRODUCTION Prurigo nodularis is an unusual disorder of unknown aetiology, which is notoriously resistant to therapy, and is characterized by extremely pruritic nodules with well-defined clinical symptoms and histopathological findings. CASE PRESENTATION We report the case of a patient presenting with pruritic papules and nodules on his legs, arms and trunk over the past 4 years, recurring a...

Abstract Prurigo is a treatment‐resistant skin disease characterized by multiple isolated papules/nodules that cause severe itch. occur either as primary lesions or secondary due to persistent scratching. The fundamental concepts and classifications of prurigo have not been sufficiently established, considerable confusion remains regarding this topic. Clinical guidelines for chronic in Japan we...

Fig. S1. (A) Upper back and (C) right lateral thigh prior to treatment on day 11. (B) Upper back and (D) right lateral thigh after treatment on day 70.

The association between actinic granuloma and giant cell arteritis (temporal arteritis) has been claimed by some authors. There is a hypothesis that actinic radiation has the principal role in the etiology of both diseases in a similar way. Here, we report a case of actinic granuloma that had characteristic pathologic features of giant cell arteritis in histopathologic examination without clini...