To the Editor: Homicide committed by older adults is an extreme and infrequent outcome of violence that has a prevalence ranging from 1% to 4%.1–4 An association of mild and moderate dementia with homicide has been reported.1,2,5–9 Although risk factors of homicide in demented patients remain unknown, dysexecutive syndrome could be a cause. The reported case highlights this issue and shows that...

A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.

A novel copper-catalyzed oxidation of arene-fused cyclic amines to the corresponding cyclic imides has been developed. The reaction can be used to synthesize 1,3-disubstituted TPD in high yields.

At 5:56 p.m. on October 23, 2004, a major earthquake of magnitude 6.8 on the Richter scale struck the Chuetsu district of Niigata Prefecture, Japan, a rural area with mountain villages. Strong aftershocks of grade 5-6 on the Japanese Intensity Scale continued for 2 months. We investigated changes in the HbA1c levels of 65 type 1 diabetic patients with insulin therapy before and throughout the 1...

The aim of this exploratory study was to compare internet sex offenders with a matched group of child molesters in the Greater London Area. Over an 8-month period 210 subjects were assessed, of whom 90 were internet sex offenders and 120 were child molesters. A wide range of background data was collected, including a number of psychometric measures to determine risk and personality traits. The ...

Young children with high levels of acting out behaviors present a challenge for families, caregivers, and the childcare system. The Parenting the Strong-Willed Child (PSWC) parenting class curriculum program is a 6-week, group based parent education program designed for parents of children with noncompliance problems (ages 2–8). The PSWC program was offered at no cost to parents enrolled in 8 H...

BACKGROUND Type 2 diabetes poses an increasing healthcare burden in Japan. Although insulin treatment has diversified in recent years, the literature on the utilization of healthcare services among patients with type 2 diabetes undergoing different insulin therapy regimens is scarce. The current study aimed to characterize the real-world insulin treatment patterns and associated utilization of ...

Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since pumps provide better glycaemic control compared to injections in humans. The aim of this stu...

Novel developmental programs often evolve via cooption of existing genetic networks. To understand this process, we explored cooption of the TAS3 tasiRNA pathway in the moss Physcomitrella patens. We find an ancestral function for this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response Factors. In moss, this results in stochastic patterning of the filam...