BACKGROUND It has been hypothesized that alteration of hormone systems is involved in the carcinogenesis of acrylamide. The aim of the present study was to examine the cross-sectional associations between dietary acrylamide intake and sex hormone levels in premenopausal Japanese women. METHODS Study subjects were 393 women who had regular menstrual cycles less than 40 days long. Acrylamide in...

In early 2002, Swedish scientists discovered unexpected high levels of acrylamide in the blood of unexposed workers leading to the hypothesis that acrylamide might be present via dietary exposure. The Swedish National Food Administration reported the presence of relevant amounts of acrylamide in starch-rich foods cooked at high temperatures, such as French fries, potato chips, baked goods, cere...

Acrylamide, widely employed as a vinyl monomer in the polymer industry, is a potent neurotoxin to man and to animals. The cumulative effect of prolonged, low-level exposure to acrylamide monomer is the insidious development of a progressive peripheral neuropathy. Sensory symptoms begin in the hands and feet (numbness, pins and needles), certain reflexes are lost and, with severe exposure, muscl...

Acrylamide is a substance occured carbohydrate-rich foods during cooking high temperature and because of its small and hydrophilic structure, it can diffuses easily throughout the body. Due to this reason all tissues teorically become the target according to the acrylamide toxicity. In this study it was investigated whether acrylamide has any effect on the renal function of the male and female ...

Alterations in axonal caliber and neurofilament content have been associated with altered neurofilament transport in several models of neurofibrillary degeneration. Acrylamide intoxication provides a prototype of distal axonal degeneration, the most frequent pattern of axonal pathology in human and experimental neurotoxic injury. Neurofibrillary changes are a variable and often minor aspect of ...

Acrylamide was grafted in low density polyethylene during melt processing in the presence of a free radical initiator using a torque rheometer in a closed system. Effects of processing time, acrylamide and benzoyl peroxide concentrations were studied. FTIR studies revealed that the degree of grafting increased by an increase in acrylamide concentration. Maximum grafting was obtained at 7 mi...

Acrylamide is a monomer widely used as an intermediate in the production of organic chemicals, e.g. polyacrylamides (PAMs). Since PAMs are low cost chemicals with applications in various industries and waste- and drinking water treatment, a certain amount of non-polymerised acrylamide is expected to end up in waterways. PAMs are non-toxic but acrylamide induces neurotoxic effects in humans and ...

Carbohydrate rich food cooked at high temperature can lead to the formation of acrylamide. The aim of this investigation is to analyze the proteomics of mice liver in response to acrylamide intoxication since the liver is the major site of acrylamide detoxification and metabolism. The liver protein pattern from sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) treated mice wi...

BACKGROUND Acrylamide is a probable human carcinogen formed during cooking of starchy foods. Two large prospective cohort studies of dietary acrylamide intake and ovarian cancer risk observed a positive association, although two other studies reported no association. METHODS We measured acrylamide exposure using red blood cell acrylamide and glycidamide hemoglobin adducts among women in two l...

INTRODUCTION Acrylamide is very toxic to various organs and associated with significant increase of oxidative stress and depletion of antioxidants. Alpha-lipoic acid enhances cellular antioxidant defense capacity, thereby protecting cells from oxidative stress. AIM OF THE STUDY This study aimed to evaluate the protective role of alpha-lipoic acid on the oxidative damage induced by acrylamide ...