The origin of desacetylcephalosporin C in cephalosporin C fermentation broths was investigated. Esterase activity was detected in cell-free extracts of Cephalosporium acremonium, but these extracts failed to deesterify cephalosporin C. When cephalosporin C was added to sterile and inoculated fermentation media, the antibiotic decayed at nearly identical rates. The formation of desacetylcephalos...

The previously published structure of the fungal metabolite acremine P is revised by re-evaluation of chemical shift values and NOESY data, and by DFT calculations.

A 23-year-old boy was hospitalized for dyspnea with mild fever. Chest x-ray documented left pleural effusion. Cultures from thoracentesis grew out Acremonium strictum and intravenous liposomal amphotericin B was given at a dose of 200 mg daily. On treatment, fever subsided but dyspnea worsened. Whole-body CT scan showed multiple bilateral lung nodules, systemic lymphadenopathies and a mass over...

A historic profile of endophyte-induced tall fescue toxicosis is presented. A chronology of events is presented, beginning with the importance of finding Balansia-infected grasses in a tall fescue pasture in north central Georgia. This initial finding was followed by the discovery that another related endophyte was present in tall fescue and other major forage grasses. This species of endophyte...

Marine fungi have been shown to be tremendous sources for new and biologically active secondary metabolites which are reflected by the increasing number of published literature dealing with compounds from this group of fungi. As a result to these efforts, more than a hundred secondary metabolites from marine fungi have been described. The mycobiota of the coastal water were collected from five ...

The effects of different additives, including lactic acid bacteria inoculants, acremonium cellulase and mixtures of lactic acid bacteria inoculants and acremonium cellulase on changes of nutritive components and in vitro digestibility of Ceratoides arborescens during ensiling were investigated. The silages of each treatment were prepared in plastic film bags, kept in an incubator at 30°C and ba...