Acne vulgaris is an extremely common disease with numerous disease associations, but it is unclear what causes the normal pilosebaceous unit to turn into an inflamed acne lesion. The bacterium Propionibacterium acnes normally lives within the pilosebaceous unit, yet many studies over the last 50 years support a role for this organism in acne pathogenesis. While the specific role of P. acnes is ...

The skin diseases are often incurable and treatments aim to reduce symptoms. Common examples include eczema, psoriasis, acne, rosacea and vitiligo. Whether these conditions are common or very rare, the impact on quality of life can be far-reaching and profound even without stigmatisation. Stigmatisation is an expression of prejudice and ignorance which the medical profession has a duty to comba...

PURPOSE (1) Investigation of dependence between first symptoms of the rosacea and with surviving of critical life events. (2) Description of the dissimilarity in intensity of the stress at illness and healthy. (3) Estimation of impact of stressful situations for escalating of changes in course of the disease. (4) Comparison of the subjective estimation of patients' health. MATERIAL AND METHOD...

Perioral dermatitis is a relatively common inflammatory facial skin disorder that predominantly affects women. It is rarely diagnosed in children. A typical perioral dermatitis presentation involves the eruption of papules and pustules that may recur over weeks to months, occasionally with fine scales. The differential diagnosis includes seborrheic dermatitis, systemic lupus erythematosus, acne...

Antimicrobial peptides (AMPs) are effector molecules of the innate immune system of the skin. They present an activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as some fungi, parasites and enveloped viruses. Several inflammatory skin diseases including psoriasis, atopic dermatitis, acne vulgaris and rosacea are characterized by a dysregulated expression of AM...

Purpose of the study: The goal of this study was to review the recent evidence regarding the pathophysiology of reactive skin, acne vulgaris and rosacea, with a focus on the link between the impaired skin barrier and the inflammasome. In this context, we evaluated the activity of Rhealba oat plantlet extract on the inflammasome in vitro. Procedures: Using an in vitro inflammatory model of Recon...

Sir, Lupus miliaris disseminatus faciei (LMDF) or acne agminata is a chronic inflammatory disorder that occurs singly or in crops on the eyelids, cheeks and nasolabial folds (1). Clinically it consists of multiple indolent bright-red or brown papules. Histologically, it is characterized by dermal masses of tuberculoid granulomas with central caseation necrosis. LMDF is currently widely consider...