IN AN EARLIER STUDY (Barr et al., 1981) we explored the pathogenesis of soft-tissue necrosis induced in guinea-pigs by the concrolled extravascular administration of cytotoxic drugs. This system provides a model of the phenomenon which may complicate the inadvertent perivenous injection of cancer chemotherapeutic agents in clinical practice. The current investigation was undertaken in order to ...

A variety of genes are involved in determining the level of organic solvent tolerance of Escherichia coli K-12. Gene ostA is one of the genes contributing to the level of organic solvent tolerance. This gene was cloned from an n-hexane-tolerant strain of E. coli, JA300. A JA300-based n-hexane-sensitive strain, OST4251, was converted to the n-hexane-tolerant phenotype by transformation with DNA ...

The asymmetric unit of the title organic-inorganic molecular salt, C6H18N2 (2+)·SiF6 (2-), consists of one anion and one cation together with half of each of two cations and two anions located on inversion centres. The SiF6 (2-) octa-hedral anions are arranged to form sheets parallel to (011), which are linked into a three-dimensional network by the organic cations through N-H⋯F hydrogen bonds.

Normal hexane is adopted as a typical organic solvent for comparison with liquid water in modern theories of hydrophobic hydration, and detailed results are worked-out here for the C-atom density in contact with a hard-sphere solute, rhoCG(R), for the full range of solute radii. The intramolecular structure of an n-hexane molecule introduces qualitative changes in G(R) compared to scaled-partic...

Fungal biofilters have been recently studied as an alternative to the bacterial systems for the elimination of hydrophobic volatile organic compounds (VOC). Fungi foster reduced transport limitation of hydrophobic VOCs due to their hydrophobic surface and extended gas exchange area associated to the hyphal growth. Nevertheless, one of their principal drawbacks is their slow growth, which is cri...

Methods are reported for the manual spectrophotometric or fluorometric estimation of tocopherol in human cerebrospinal fluid. The fluid is centrifuged, an equal volume of ethanol is added, and the tocopherol is extracted with hexane, which is then used for the direct estimation by fluorometry. The fluorescence of tocopherol is significantly affected by the proportion of ethanol in the hexane so...

Abstract: In this study, the liquid-liquid equilibria of the mixtures consisted of ethanol, water, and the main components of gasoline fuel: pentane, hexane, and cyclohexane were experimentally determined. This study is related to the phase behavior when water in atmosphere is absorbed into ethanol + gasoline fuel (gasohol) and then possibly separates into two liquid phases in an automobile fue...

Health risks posed by dermal contact with PCB-contaminated porous surfaces have not been directly demonstrated and are difficult to estimate indirectly. Surface contamination by organic compounds is commonly assessed by collecting wipe samples with hexane as the solvent. However, for porous surfaces, hexane wipe characterization is of limited direct use when estimating potential human exposure....

n-Hexane and methyl n-butyl ketone share a common metabolite, 2,5-hexanedione, a potent neurotoxin. Neurotoxic effects to both peripheral and central nervous systems may occur after occupational exposure or recreational abuse of n-hexane. Initial clinical manifestations include numbness and tingling sensation in the toes and fingers, followed by progressive weakness and areflexia, particularly ...

The urinary excretion of the n-hexane metabolite 2,5-hexanedione (HD) was determined in four shoe factory workers during four workingdays that were preceded by four free days and followed by two free days. The correlation between excretion of HD and the n-hexane concentrations in the workroom air was evaluated. The air concentrations of n-hexane and those of acetone, toluene, and other organic ...