Hydrazine (HD) and acetylhydrazine (AcHD) are metabolites of the antituberculosis drug isoniazid (INH) that have been implicated in INH-induced liver damage. The hepatotoxicity of AcHD and HD were compared in adult male C57Bl/6J mice by evaluating hepatic histopathology, plasma biochemistry, and hepatic gene expression. By all measures, HD had significantly greater effects than AcHD. There was ...

The title compound, C14H16N6O2, is a second monoclinic polymorph of 2-[1-(3,5-dimeth-yl)pyrazol-yl]-2-hy-droxy-imino-N'-[1-(2-pyrid-yl)ethyl-idene] acetohydrazide, with two crystallographically independent mol-ecules per asymmetric unit. The non-planar mol-ecules are chemically equal having similar geometric parameters. The previously reported polymorph [Plutenko et al. (2012 ▶). Acta Cryst. E6...

The title compound, C(11)H(14)N(2)O(2), was prepared by the reaction of acetohydrazide and 1-(4-methoxy-phen-yl)ethanone. In the mol-ecule, all bond lengths and angles are within normal ranges. In the crystal structure, adjacent mol-ecules are linked into a centrosymmetric dimer by inter-molecular N-H⋯O hydrogen bonding.

Recently Bartoli et all described a patient with acute hepatic necrosis that occurred two days after treatment with hydrallazine 50 mg daily. The diagnosis was supported by biopsy and rechallenge with the drug. The patient was definitely jaundiced and complained of right upperquadrant pain with nausea and vomiting. We think that our case is important because it provides corroborative evidence o...

In this work, we describe the design, synthesis and pharmacological evaluation of novel imidazo[1,2-a]pyridine-N-glycinyl-hydrazone derivatives (1a-k) intended for use as inhibitors of tumor necrosis factor alpha (TNF-α) production. The compounds were designed based on the orally active anti-inflammatory prototype LASSBio-1504 (2), which decreases the levels of the pro-inflammatory cytokine TNF...

The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2- phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthes...

Herpes zoster (HZ) is a painful, blistering skin eruption in a dermatomal distribution caused by reactivation of a latent varicella zoster virus in the dorsal root ganglia (DRG). Post-herpetic neuralgia (PHN) is the most common complication of acute herpes zoster (AHZ).Severe prodrome, greater acute pain and dermatomal injury, and the density of the eruption are the risk factors and predictors ...

Isoniazid (INH) is associated with serious liver injury and autoimmunity. Classic studies in rats indicated that a reactive metabolite of acetylhydrazine is responsible for the covalent binding and toxicity of INH. Studies in rabbits suggested that hydrazine might be the toxic species. However, these models involved acute toxicity with high doses of INH, and INH-induced liver injury in humans h...

Yazma eser kütüphanelerinde silsilenâme türünde pek çok bulunmaktad?r. Bunlardan biri Acemzâde Mustafa Cemâlî’nin Silsilenâme-i Mevleviyye adl? eseridir. Cemâlî, Üsküp Tekkesi ?eyhi Hasan b. esSinânî’nin o?ludur. Mevlevîlik tarikat?na mensuptur. Zaviyesi dervi?lerindendir. Silsile-i Mevleviyye’de yer alan manzumelerden Cemâlî mahlas?yla ?iirler yazd??? anla??lmaktad?r. Ancak ?airlik yetene?i k?...