BACKGROUND An acetylcholinesterase inhibitor donepezil currently is used to treat patients with Alzheimer disease. However, its direct effect on cerebral blood vessels has not been evaluated. The present study was designed to examine whether donepezil induces acute cerebral arteriolar dilation and whether neuronal nitric oxide synthase contributes to this vasodilator response. METHODS Brain s...

Abstract Alzheimer’s disease (AD) is a multifactorial neurodegenerative central system with high prevalence among the elderly and most common form of dementia. Oxidative stress crucial on AD pathogenesis leads to deposition neurofibrillary tangles Aβ plaques; therefore, use natural antioxidants or ROS scavengers could help avoid formation these aggregates. Similarly, Aβ-degrading/anti-aggregati...

the short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. rats were injected daily with varying amounts of chromium. the short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respectively. acetylcholinesterase activity was also re...

Alzheimer's disease is a progressive age-related brain disorder. It causes gradual memory loss, changes in personality traits, confusion, impaired thinking, and mood Acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) inhibitors have been chosen for the treatment of Alzheimer’s disease. Dual cholinesterase become new hotspot investigation anti-Alzheimer's drugs. The current study was desi...

Thiên niên kiện lá lớn đã được sử dụng trong y học cổ truyền từ lâu đời. Các đặc điểm vi phẫu và thành phần bột dược liệu của loài này vẫn chưa mô tả một cách toàn diện. Nghiên cứu phẫu, soi bột, đánh giá hoạt tính ức chế acetylcholinesterase chống oxy hoá lớn. bằng phương pháp kính hiển vi. Hoạt enzyme Ellman hóa thực hiện trên hình loại bỏ gốc tự do 2,2-diphenyl-1-picrylhydrazyl (DPPH). Đây l...