We here report the first total synthesis of Streptococcus pneumoniae serotype 1 (Sp1) oligosaccharide, a unique zwitterionic capsular polysaccharide carrying labile O-acetyl esters. The target oligosaccharides, featuring rare a-2,4-diamino-2,4,6-trideoxy galactose (AAT) and a-galacturonic acids, were assembled up to 9-mer level, in highly stereoselective manner using trisaccharide building bloc...

N-acetyl glutamate synthase (NAGS) is the first enzyme in arginine biosynthetic pathway and catalyzes transfer of an acetyl group from acetyl-CoA to L-glutamate produce N-acetylglutamate (NAG). NAGS enzymes either consist two domains (classical NAGS) or a single domain (short S-NAGS). S-NAGS, although present many bacteria, have not been well characterized date. This study's focus kinetically c...

THEORETICAL AND EXPERIMENTAL STUDY OF STRUCTURE REACTIVITY RELATED TO METABOLISM TOXICITY PARACETAMOL. An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, chemical reactivity using frontier orbitals Fukui index were used explaining main p...

b a ckground: the role of lectins is important in interaction between pathogens and mosquito vectors. this study was performed to identify agglutinin activities of protein molecules on the midgut of culex pipiens . m e t hods: c u lex pipiens was reared in insectray condition and the midguts of males and females (blood fed and un- fed) were dissected separately in tris-hcl buffer. the extracts ...

N-Acetyl-d-neuraminic acid (NeuAc), a well-known and well-studied sialic acid, is found in cell surface glycolipids glycoproteins, where it performs variety of biological functions. The use NeuAc as nutraceutical for infant brain development an intermediate pharmaceutical production demands its on industrial scale. Natural extraction, chemical synthesis, enzymatic biosynthesis are the methods u...