This enzyme has assumed considerable importance in studies of enzymatic acetylations since the coupling of Reaction 1 with specific CoA-linked acetyl acceptor enzyme systems (1, 3, 8-10) permits the use of acetyl phosphate as a source of acetyl groups. In the present paper a partial purification of transacetylase from extracts of Clostridium kluyveri is described and some properties of the enzy...

Background: This study was undertaken to investigate whether treatment with vitamin E and N acetyl cystein protects rat sperm by inhibiting reactive oxygen species generation induced by lead (Pb) exposure. Materials and Methods: After an acclimatization period of one week, 20 Male rats were divided into 4 groups of 5 rats each. Animals within different treatment groups were maintained on their ...

We have presented evidence that stimulation of pyruvate dehydrogenase, (PDH.) kinase activity by pyruvate or by acetyl-CoA is mediated through acetylation of lipoyl moieties (Cate, R. L., and Roche, T. E. (1978) J. Biol. Chem. 253,496-503). In accord with this indirect mechanism for the action of these effecters, we now find that the degree of stimulation of PDH, kinase increases with the level...

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD(+)-dependent mechanisms to deacetylate acetyl lysine substrates. Although removal of histone acetyl epigenetic modification by HDACs regulates chromatin structure and tra...

Urinary N-acetyl-β-D-glucosaminidase is a marker of early tubular damage. Therefore, the current study was to investigate effects and its underling mechanisms valsartan on gentamicin induced renal injury through urinary parameter variety in rats. Animals were divided into four groups consisting 12 rats each. The lasted for 10 d. Rats treated two batches 6th 11th d experiment, with 6 each group....

The sialic acids can have O-acetyl esters at the 4, 7, 8, and 9 positions. Most methods for the detailed study of such molecules require their release from glycosidic linkage, followed by extensive purification. The currently used methods for release and purification of sialic acids allow a reasonable qualitative analysis of the diversity of sialic acids from a given biological source. However,...

-l. Significant levels of aryl acylamidase (E.C. 3.5.1:13) activity have been found in extracts of larvae of the webbing clothes moth, Tineola bisselliella using acetyl p-nitroanilide as substrate. 2. Gel electrophoresis suggests that the activity is due to more than one enzyme. Inhibitor studies show that these enzymes are probably of the "active serine" type but have a requirement for a free ...

As a follow-up to our effort establish reliable thermodynamic data for amino acids, the heat capacity and phase behavior are reported N-acetyl glycine amide (CAS RN: 2620-63-5), N-acetyl-L-alanine 15962-47-7), N-acetyl-L-valine 37933-88-3), N-acetyl-L-isoleucine 56711-06-9), N-acetyl-L-leucine 28529-34-2). Prior measurement, thermogravimetric analysis X-ray powder diffraction were performed det...

The deep dichotomy of archaea and bacteria is evident in many basic traits including ribosomal protein composition, membrane lipid synthesis, cell wall constituents, and flagellar composition. Here we explore that deep dichotomy further by examining the distribution of genes for the synthesis of the central carriers of one carbon units, tetrahydrofolate (H4F) and tetrahydromethanopterin (H4MPT)...

The title compound, C(16)H(12)O(6), is a common impurity of ortho-acetyl-salicylic acid (aspirin). The benzene rings form a dihedral angle of 81.9 (1)° while the acetyl and carboxyl groups form dihedral angles of 74.0 (1) and 26.4 (2)°, respectively, with the benzene rings to which they are bound. In the crystal, mol-ecules are linked by pairs of O-H⋯O hydrogen bonds between the carboxyl groups...