The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared an...

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study...

Introduction: Nonsteroidal anti-inflammatory drugs are the most commonly used drugs to reduce pain and inflammation. Aceclofenac is a newer derivative of diclofenac with less gastrointestinal complications. The objective of the present study was to evaluate the toxicity profile of sustain release aceclofenac injection in rats at three dose levels, ranging from 2 to 10 mg/kg body weight. Mater...

This work introduces three eco-friendly UV spectrophotometric methods for the simultaneous estimation of Paracetamol, Aceclofenac and Eperisone Hydrochloride in pharmaceutical tablet formulation. The procedures employed were equation method multivariate chemometric with phosphate buffer pH 7.80 as diluent. encompasses absorbance measurement at different wavelengths (λmax drugs). It exhibits lin...

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

Toxic epidermal Necrolysis (TEN) are serious disorders commonly termed as idiosyncratic reactions to drug, the most common being antiepileptic(phenytoin, barbiturates, carbamazepine and lamotrigine), sulfonamides, trimethoprim, ampicillin, allopurinol and NSAIDS (especially phenylbutazone and oxicam derivatives). Here we report a case of TEN in a patient who developed the lesion after oral admi...

aceclofenac is a non-steroidal anti-inflammatory drug (nsaid) that exhibits analgesic, antipyretic and anti-inflammatory activities. it is practically insoluble in water. the effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. the enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

A topical preparation containing aceclofenac was developed using an o/w microemulsion system. Isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. Pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (Labrasol) and co-surfactant (plurol oleique) for microemulsion formation. Five different formulations were formul...

Aceclofenac, 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acidis a non-steroidal antiinflammatory drug (NSAID) used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Simple, rapid, accurate, specific and highly sensitive UV spectroscopic methods were developed and validated for the estimation of Aceclofenac in bulk and phar...

The objective of the present work is extraction of pectin from waste of orange fruit peel and further characterization for useful alternative pharmaceutical excipient. The pectin was subjected to phytochemical and physicochemical characterization of its safety and suitability to use as binding and suspending agent. FT-IR spectroscopy, DSC studies were performed for drug, orange peel pectin powd...