PURPOSE Single-agent histone deacetylase inhibitors (HDACi) have limited clinical activity in human leukemia. Although the way HDACi exert their antileukemia effect is not fully understood, it is accepted that induction of apoptosis is important. We hypothesized, therefore, that combination of an HDACi with a proapoptotic agent, such as the Bcl-2 homology domain-3 mimetic GX15-070, could result...

To solve the problem of resonance during quasi-static calibration of high-g accelerometers, we deduce the relationship between the minimum excitation pulse width and the resonant frequency of the calibrated accelerometer according to the second-order mathematical model of the accelerometer, and improve the quasi-static calibration theory. We establish a quasi-static calibration testing system, ...

On the circular curve, lateral acceleration affects comfort. On the spiral, both lateral acceleration and jerk affect comfort.  The determination of maximum curving speed on the basis of lateral acceleration only is not critical because the lateral acceleration is proportional to the square of speed whereas jerk is proportional to cubic power of speed. The maximum speed on a curve is thus signi...

A multidimensional cosmological model describing the dynamics of n+1 Ricci-flat factor-spaces Mi in the presence of a one-component anisotropic fluid is considered. The pressures in all spaces are proportional to the density: pi = wiρ , i = 0, ..., n . Solutions with accelerated expansion of our 3-space M0 and small enough variation of the gravitational constant G are found. These solutions exi...

in this paper, the effect of bedrock inclination on seismic performance of slopes is investigated. the study was conducted based on dynamic analysis of different slopes, evaluation of the earthquake acceleration in sliding mass, and calculating the permanent displacement of the slope, using newmark sliding block. the investigation indicates that variation of the bedrock inclination may cause th...

President, Staff Society N. A. Kshirsagar Editor Atul Goel Associate Editors Sandeep Bavdekar Lakshmi Rajgopal Consulting Editors Nithya Gogtay Sanjay Mehta Vinita Salvi Managing Editor D. K. Sahu Members Amita Athavale Abhay Dalvi Sucheta Dandekar Hemant Deshmukh Anil Patwardhan Preeti Mehta Nalini Shah Lalita Tuteja Pradeep Vaideeswar S. V. Vaidya Editorial Assistants Shilpa Abhyanakar Jignes...

semi-active base isolation system has been proposed mainly to mitigate the base drift of isolated structures while in most cases, its application causes the maximum acceleration of superstructure to be increased. in this paper, designing optimal semi-active base isolation system composed of linear base isolation system with low damping and magneto-rheological (mr) damper has been studied for co...