Acetyl-CoA carboxylase (ACC) catalyzes the formation of malonyl-CoA, a precursor in the biosynthesis of long-chain fatty acids, which have been implicated in physiological insulin secretion. The catalytic function of ACC is regulated by phosphorylation (inactive)-dephosphorylation (active). In this study we investigated whether similar regulatory mechanisms exist for ACC in the pancreatic islet...

Chen J, Jeppesen PB, Nordentoft I, Hermansen K. Stevioside improves pancreatic -cell function during glucotoxicity via regulation of acetyl-CoA carboxylase. Am J Physiol Endocrinol Metab 292: E1906 –E1916, 2007. First published March 6, 2007; doi:10.1152/ajpendo.00356.2006.—Chronic hyperglycemia is detrimental to pancreatic -cells, causing impaired insulin secretion and -cell turnover. The char...

Adaptive Cruise Control (ACC) is assumed to have a potential to improve quality-of-service and safety and to reduce the environmental impact of the road traffic system. This paper use vehicle trajectories from traffic simulation to study impacts of ACC on vehicle acceleration and deceleration rates. The analysis is based on traffic simulations with car-following models including ACC functionali...

Previous studies have found no agreement on whether anticipatory activity in the anterior cingulate cortex (ACC) reflects upcoming conflict, error likelihood, or actual control adjustments. Using event-related functional magnetic resonance imaging, we investigated the nature of preparatory activity in the ACC. Informative cues told the participants whether an upcoming target would or would not ...

Adrenocortical carcinoma (ACC) is a rare, but aggressive endocrine malignancy with a generally poor clinical outcome. There is no effective therapy for advanced and metastatic ACC. In our study, we found that an existing drug (rottlerin) exerted its tumour-suppressive function in ACC. Specifically, rottlerin inhibited cellular proliferation of ACC cell lines (NCI-H295R and SW-13) in a dose- and...

This paper reports on nonintrusive methods for characterizing the longitudinal performance of vehicles equipped with adaptive cruise control (ACC) systems. It reports the experimental set-up and procedures for measuring ACC system performance, followed by the modeling and simulation of the measured ACC performance. To further assess the interaction of ACC vehicles with human-controlled traffic,...

Methods for light and electron microscopic identification and characterization of intestinal cholera antitoxin-containing cells (ACC) using peroxidase-labeled immunoreagent are described and used to study the ACC response in mice after immunizations with cholera toxin. Specific ACC appeared in significant numbers after two oral immunizations and increased six- to eightfold with two additional o...

Intracellular triacylglycerol (TG) content of liver and skeletal muscle contributes to insulin resistance, and a significant correlation exists between TG content and the development of insulin resistance. Because acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme for liver fatty acid biosynthesis and a key regulator of muscle fatty acid oxidation, we examined whether ACC plays a role in ...