genetic improvement programs may improve disease resistance in animal production. the best-characterized genetic control of disease resistance and immune response in animals is the one associated with the major histocompatibility complex (mhc). the ovine lymphocyte antigenof drb1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

The major histocompatibility complex (MHC) in chickens influences disease resistance, but the mechanism is not understood. In Leghorn lines, the MHC contains 2 closely-linked class I loci, B-FI and B-FIV. Previously, we determined nucleotide sequences of well-expressed class I (B-F) genes from unique MHC haplotypes of broiler chicken lines. More recently, we identified 7 new B-F alpha1alpha2-co...

Di Maso, Nick A., Vincent J. Caiozzo, and Kenneth M. Baldwin. Single-fiber myosin heavy chain polymorphism during postnatal development: modulation by hypothyroidism. Am J Physiol Regulatory Integrative Comp Physiol 278: R1099–R1106, 2000.—The primary objective of this study was to follow the developmental time course of myosin heavy chain (MHC) isoform transitions in single fibers of the roden...

One may wonder why the genes for the class III region are even situated in the human Major Histocompatibility Locus (MHC). However, on closer inspection we find that the genes for the complement components, tumor necrosis factor (TNF) and others may play an important role in host immune defenses. Thus, this region on chromosome six may be more appropriately thought of as an immune response area...

BACKGROUND Molecules of the class II major histocompability complex (MHC-II) specifically bind and present exogenously derived peptide epitopes to CD4+ T helper cells. The extreme polymorphism of the MHC-II hampers the complete analysis of peptide binding. It is also a significant hurdle in the generation of MHC-II molecules as reagents to study and manipulate specific T helper cell responses. ...

The Campero-INTA chicken of Argentina was developed to provide a robust bird that can survive under Argentinian pasture conditions with no significant additional nutrition, producing source animal protein for small producers or low-income families. In previous work, we described the AH paternal line Campero and its Major Histocompatibility Complex B region (MHC-B) variation. this work analyzed ...

The major histocompatibility complex (MHC) forms an integral component of the vertebrate immune response and, due to strong selection pressures, is one of the most polymorphic regions of the entire genome. Despite over 15 years of research, empirical studies offer highly contradictory explanations of the relative roles of different evolutionary forces, selection and genetic drift, acting on MHC...

1. Abstract 2. Introduction 3. MHC Class I and II Molecules 3.1. Function of MHC Class I and Class II molecules 3.2. Structure of MHC Class I and Class II molecules 3.3. Antigen binding by MHC Class I and Class II molecules 3.4. MHC polymorphism on peptide binding 3.5. Antigen presentation by MHC Class II molecules 4. MHC and disease associations 4.1. Associations between MHC polymorphism and d...

Complementary DNA (cDNA) clones corresponding to the major histocompatibility (MHC) class III antigen, complement protein C2, have been isolated from human liver cDNA libraries with the use of a complex mixture of synthetic oligonucleotides (17 mer) that contains 576 different oligonucleotide sequences. The C2 cDNA were used to identify a DNA restriction enzyme fragment length polymorphism that...

Pathogen selection is postulated to drive MHC allelic diversity at loci for antigen presentation. However, readily apparent MHC infectious disease associations are rare in most species. The strong link between MHC-B haplotype and the occurrence of virally induced tumors in the chicken provides a means for defining the relationship between pathogen selection and MHC polymorphism. Here, we verifi...