Short-term abstinent alcoholics have shown increased engagement of reward regions and reduced engagement of executive control regions. There is no report yet on whether these differences can predict relapse. This is the first study that investigates whether differences in resting-state networks can predict later relapse. Resting-state functional magnetic resonance imaging data were collected fr...

OBJECTIVE To document the management of and outcomes for patients receiving narcotic replacement and tapering with long-acting morphine preparations during pregnancy. DESIGN A prospective cohort study over 18 months. SETTING Northwestern Ontario. PARTICIPANTS All 600 births at Meno Ya Win Health Centre in Sioux Lookout, Ont, from January 1, 2012, to June 30, 2013, including 166 narcotic-e...

PURPOSE The purpose of this focused ethnography was to describe the culture of care and nonpharmacologic nursing interventions performed by NICU nurses for infants with neonatal abstinence syndrome (NAS). METHOD Roper and Shapira's framework for the analysis included participant observation, individual interviews, and examination of existing documents. SAMPLE Twelve full-time nurses were ob...

OBJECTIVE The objective of the study was to identify maternal variables predicting length of treatment for neonatal abstinence syndrome (NAS). STUDY DESIGN This was a retrospective cohort study of infants treated for NAS during 2000-2006 whose mothers were on methadone maintenance at delivery. Mixed-effects linear regression was used to examine the interaction of maternal and neonatal variabl...

Ontario's clinical practice guidelines for neonatal abstinence syndrome (NAS) provide evidence-informed recommendations that address the needs of substance using pregnant women and newborns at risk of NAS. NAS is a complex and multifaceted issue that is escalating along with rapidly rising opioid use in Ontario. Reducing the incidence and impact of NAS requires immediate action in order to impr...

background and objectives: patients experience moderate to high level of anxiety before cardiac catheterization. this study aimed to investigate the effect of voice of quran on anxiety before cardiac catheterization. methods: in this randomized controlled trial, 60 patients who met the inclusion criteria were conveniently sampled and randomly allocated to the experimental and control groups. in...

Abstinence from sexual intercourse represents a healthy hoice for teenagers, as teenagers face considerable risk to heir reproductive health from unintended pregnancy and exually transmitted infections (STIs) including infection ith the human immunodeficiency virus (HIV). Remaining bstinent, at least through high school, is strongly supported y parents and even by adolescents themselves. Howeve...

OBJECTIVE The aim of this study was to evaluate the influence of different periods of abstinence on conventional semen parameters as well as functional parameters in human semen, including mitochondrial function, chromatin packing and sperm DNA fragmentation. METHODS We recruited a cohort of 2,458 men undergoing infertility investigation. Semen analyses were performed according to WHO guideli...

BACKGROUND AND OBJECTIVE Neonatal abstinence syndrome (NAS), a self-limiting condition, is associated with clinical symptoms that may require pharmacological intervention. Optimal treatment of NAS remains undetermined, but the hospital length of stay (LOS) for patients with NAS is partially dependent upon a standard treatment protocol used. Prolonged LOS for patients with NAS can lead to advers...

BACKGROUNDS Evaluating the efficacy of the loading and tapering dose of Phenobarbital versus oral Morphine in the management of NAS. METHODS This randomized, open-label, controlled trial was conducted on 60 neonates born to illicit drugs dependent mothers at Vali-Asr and Akbar-Abadi hospitals, Tehran, Iran, who exhibited NAS requiring medical therapy. The neonates were randomized to receive e...