In 22 patients with femoral neck fractures 99mTc-MDP scintimetry was performed before operation and again shortly after operation; in 17 of these patients the investigation was repeated after four months. Six patients with increased uptake in the femoral head before operation and eight with decreased uptake had similar results at the first postoperative investigation. Of eight patients with an ...

Activation of peritoneal macrophages from guinea pigs by various bacterial cell walls, M-1 endo-N-acetylmuramidase enzymatically digested bacterial cell walls and synthetic muramyl dipeptides was studied in terms of stimulation of [14C] glucosamine incorporation. All test bacterial cell wall preparations significantly increased a [14C]glucosamine uptake by the macrophages. Some of the water-sol...

Received 1/17/2005; revised 3/26/2005; accepted 4/1/2005. For correspondence or reprints contact: Chin-Ho Tsao, M.D., Division of Nuclear Medicine, Mackay Memorial Hospital, 92 Section 2, Chung-Shan North Road, Taipei 104, Taiwan. Tel: (886)2-25433535 ext. 2241, Fax: (886)2-25433535 ext. 2925, E-mail: [email protected] A 60-year-old male complained of progressing pale and jaundice in re...

a 10-year-old boy was referred to us for evaluation of fuo accompanied with bone pain in both calves. three hours after intravenous injection of 13 mci of 99mtc-mdp, whole body scan in multiple spot views was performed. the scan showed symmetrical areas of diffusely increased tracer uptake in multiple long bones. histopathologic evaluation confirmed osteosclrosis and fibrotic changes without an...

PURPOSE 99mTechnetium methylene diphosphonate (99mTc MDP) bone scintigraphy is currently the method of choice for the detection of bone metastases, but 18F-fluoro-deoxy-D-glucose positron emission tomography (18FDG PET) offers superior spatial resolution and improved sensitivity. We have compared 18FDG PET with 99mTc MDP bone scintigraphy in patients with skeletal metastases from breast cancer ...

body skeletal scintigraphy performed with 20 mCi (740 Mega Becquerel) of Technetium-99m Methylene DiphosPhonate (MDP) revealed diffusely increased tracer uptake over body of sternum and manubriosternal junction suggestive of neoplastic process. A focal area of benign uptake was also seen over left 2nd costochondral junction (Fig. 3). Contrast enhanced CT study revealed mixed sclerotic and lytic...

Osteopetrosis, also known as marble bone disease, is a clinically rare genetic disease, which represents a heterogeneous group of rare, inherited bone dysplasias that share the hallmark of abnormally increased bone density caused by osteoclast dysfunction. Hereby, the authors describe a case of osteopetrosis that showed increased diffuse radioactive uptake on whole body bone Tc-methylene diphos...

We report a case of esophageal carcinoma that showed extraosseous accumulation of 99mTc-MDP in lymph node metastases to the cervical and paracardial lymph nodes. There are few cases showing abnormal extraosseous accumulation of 99mTc-MDP in esophageal cancer lesion. The patient was a 53-year-old man with advanced esophageal cancer. Bone scintigraphy demonstrated extraosseous accumulations in le...

The nuclear medicine literature is rich with reports of both normal and abnormal accumulation of bone imaging agents (99m Tc-HDP, MDP or PYP) in extra-skeletal structures. The cases published in this issue of the Journal of Nuclear Medicine Technology are excellent examples of this phenomenon. Extraskeletal uptake is usually an incidental finding on the bone scan, although the bone scan occasio...