cerebrovascular attack (cva) and transient ischemic attack (tia) are major causes of emergency department visits around the globe. a significant number of these patients may experience repeat attacks if left untreated. several risk stratifying scoring systems have been developed in recent years to point out the high risk patients. abcd 2 is based on age, blood pressure, clinical status, diabete...

ผู้วิจัยศึกษาความเสี่ยง อุบัติการณ์และความชุกของการเกิดโรคหลอดเลือดสมองในช่วง 12 เดือนหลังเกิดภาวะสมองขาดเลือดชั่วคราว และศึกษาความสัมพันธ์ระหว่างค่าคะแนนความเสี่ยง และระดับความเสี่ยงซึ่งจำแนกด้วย ABCD2 ที่สัมพันธ์กับการเกิดโรคหลอดเลือดสมอง ใช้ข้อมูลจากแฟ้มเวชระเบียนผู้ป่วยโรคสมองขาดเลือดชั่วคราวทั้งหมดที่เข้ารักษาในหอผู้ป่วยโรคหลอดเลือดสมอง โรงพยาบาลศูนย์ขนาด 750 เตียง ตั้งแต่เดือนธันวาคม พ.ศ. 2554 - กันยายน 2558 จำนวน 157 ...

Objectives: Dizziness and vertigo account for about 4 million emergency department (ED) visits annually in the United States, and some 160,000 to 240,000 (4% to 6%) have cerebrovascular causes. Stroke diagnosis in ED patients with vertigo/dizziness is challenging because the majority have no obvious focal neurologic signs at initial presentation. The authors sought to compare the accuracy of tw...

Letter by Bhupali and Labovitz Regarding Article, “Clinical Scores for Predicting Recurrence After Transient Ischemic Attack or Stroke: How Good Are They?” To the Editor: Lemmens et al were unable to validate several prediction models of stroke recurrence after transient ischemic attack (TIA) or minor stroke and suggest that methodological differences between studies explain the variation. Howe...

Improved outcomes were observed in transient ischemic attack (TIA) patients after implementation of recommendations for stroke management and after multiple interventions such as public campaigns focused on raising awareness of stroke and reorganization of health services. The aim of this study was to describe reorganization of in-hospital services to improve the management of patients suspecte...

BACKGROUND AND PURPOSE The ABCD system was derived to predict early risk of stroke after transient ischemic attack. Independent validations have reported conflicting results. We therefore systematically reviewed published and unpublished data to determine predictive value and generalizability to different clinical settings and users. METHODS Validations of the ABCD and ABCD2 scores were ident...

Childhood cerebral adrenoleukodystrophy (CCER), adrenomyeloneuropathy (AMN) and AMN with cerebral demyelination (AMN-C) are the main phenotypic variants of X-linked adrenoleukodystrophy (ALD). It is caused by mutations in the ABCD1 gene encoding a half-size peroxisomal transporter that has to dimerize to become functional. The biochemical hallmark of ALD is the accumulation of very-long-chain f...

ATP-binding cassette (ABC) transporters facilitate unidirectional translocation of chemically diverse substances, ranging from peptides to lipids, across cell or organelle membranes. In peroxisomes, a subfamily of four ABC transporters (ABCD1 to ABCD4) has been related to fatty acid transport, because patients with mutations in ABCD1 (ALD gene) suffer from X-linked adrenoleukodystrophy (X-ALD),...