. introduction global warming and its result, climate change is an important subject investigated especially in the recent decades by researchers throughout the world. in these studies, at first, climatic parameters changes are investigated. considering many uncertainties in the parameters estimation, it is better to choose a method in order to study and analyze the uncertainty band due to diff...

To investigate a1B-adrenoceptor function, we developed a phosphorothioate antisense oligodeoxynucleotide (AO) to inhibit the expression of the a1B-adrenoceptor subtype in DDT1 MF2 cells. We measured the cellular uptake of the AO and its effect on a1B-adrenoceptor mRNA expression, protein density, and coupling to phospholipase C. Cells treated with either a control oligodeoxynucleotide (CO) or m...

introduction numerous studies have demonstrated the relationship between the amount of co2 in the atmosphere and climate change. in this respect, developed countries have an undeniable role and cause serious damage to earth environment throughout the world. ipcc’ forth evaluation report implies that adding greenhouse gases to the atmosphere during recent decades prevents the heat rays to emit w...

Selective inactivation of a1B-adrenoceptor (AR) by the sitedirected alkylating agent chlorethylclonidine (CEC) has been used as one of major pharmacological criteria to subclassify a1-AR; however, the mechanism for the differential CEC sensitivity of the two subtypes is uncertain, and the extent of CEC inactivation varies depending on the treatment employed. In this study, we examined the corre...

Kirsten R. McDonald, Neva J. Fudge, Janine P. Woodrow, James K. Friel, Ana O. Hoff, Robert F. Gagel, and Christopher S. Kovacs Faculty of Medicine Endocrinology, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6; Department of Biochemistry and Pediatrics, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3X9, Canada; and University of Texas MD Anderson Cancer...

Climate and tourism are strong correlated. Urban areas have a relevance concerning not only to cultural tourism but also for recreation. The high discussed topic of global change is focused in the tourism climatology as well. We analyzed exemplarily the climate potential and its variation of Freiburg. The analysis is based on the simulations of the regional climate models REMO and CLM for the A...

A two-stage methodology is developed to obtain future projections of daily relative humidity in a river basin for climate change scenarios. In the first stage, Support Vector Machine (SVM) models are developed to downscale nine sets of predictor variables (large-scale atmospheric variables) for Intergovernmental Panel on Climate Change Special Report on Emissions Scenarios (SRES) (A1B, A2, B1, ...