statement of problem: it is yet unclear whether fiber-reinforced composite posts can enhance the mechanical properties and prevent vertical fractures of teeth under chewing loads. purpose: the purpose of this study was to compare the fracture resistance and failure mode of endodontically treated teeth restored with three different post systems. materials and methods: thirty-six maxillary canine...

Thiopeptides are potent antibiotics that inhibit protein synthesis. They are made by a remarkable post-translational modification process that transforms a linear peptide into a polycyclic structure. We present here the in vitro biosynthesis of the core scaffold of thiomuracin catalyzed by six proteins. We show that cyclodehydration precedes dehydration, and that dehydration is catalyzed by two...

Exposure to a cold environment increased the incorporation of labeled pantothenic acid (PaA) into the liver and total PaA content. These increases were mainly due to an increase of free coenzyme A (CoA). The specific activity of the free CoA fraction was particularly high. These results suggest that exposure to a cold environment accelerates the rate of synthesis of CoA from PaA in the liver.

ADP-ribosylation is a posttranslational modification that is emerging as a broadly used mechanism to regulate the functions of proteins and their interactions. Recent findings by three groups (Ahel et al., 2009; Gottschalk et al., 2009; Timinszky et al., 2009) establish that proteins with macrodomains bind poly-ADP-ribose to mediate the cellular response to DNA damage.

One of the most important problems for distribution companies is to find the best locations for depots and to find proper routes for transportation vehicles and to optimize supply network. This study intends to develop a model for the problem of location-routing in post offices. So, a new Bi-Objective Location-Routing Problem for Locating Town Post Office and Routing Parcels is defined. This pr...

introduction: prefabricated metal and ceramic posts can be used with different kinds of core materials as an alternative to the conventional casting post and cores. it is unclear how these post and core systems can withstand different kind of forces in the mouth. the purpose of this study was to compare the fracture strength of endodontically treated, crowned maxillary incisors restored with ca...

introduction: tonsillectomy is one of the most common surgeries in the world and the most common problem is post-tonsillectomy pain and bleeding. the relief of postoperative pain helps increase early food intake and prevent secondary dehydration. one method for relieving pain is peritonsillar injection of epinephrine along with an anesthetic, which has been shown to produce variable results in ...