Although we and other studies indicated ZNF217 expression was increased in prostate cancer (PCa), the factors mediating its misregulated expression and their oncogenic activity remain largely unexplored. Recent evidence demonstrated that ferroportin (FPN) reduction lead to decreased iron export and increased intercellular iron that consequently aggravates the oncogenic effects of iron. In the p...

The c-myb promoter contains multiple GGA repeats beginning 17 bp downstream of the transcription initiation site. GGA repeats have been previously shown to form unusual DNA structures in solution. Results from chemical footprinting, circular dichroism and RNA and DNA polymerase arrest assays on oligonucleotides representing the GGA repeat region of the c-myb promoter demonstrate that the elemen...

The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor regulates extracellular calcium concentrations and is therefore important for mineral homeostasis. ROS 17/2.8 cells, a rat osteoblast-like osteosarcoma cell line, express the PTH/PTHrP receptor and provide a good model for examining the transcriptional regulation of its gene. The rat PTH/PTHrP receptor gene has two promoters, U1...

Antigen targeted immunotherapies might represent a novel treatment for B-cell chronic lymphocytic leukemia (B-CLL). We screened the mRNA expression of tumor-associated antigens (TAAs) from the literature (fibromodulin, survivin, OFA-iLRP, BAGE, G250, MAGE1, PRAME, proteinase, syntaxin, hTERT, WT-1) and TAAs defined previously by serological analysis of cDNA expression libraries from leukemic ce...

KRAS is mutated in >90% of pancreatic ductal adenocarcinomas. As its inactivation leads to tumour regression, mutant KRAS is considered an attractive target for anticancer drugs. In this study we report a new delivery strategy for a G4-decoy oligonucleotide that sequesters MAZ, a transcription factor essential for KRAS transcription. It is based on the use of palmitoyl-oleyl-phosphatidylcholine...

The question, how true concurrency differs from interleaving, has been studied intensively, beginning with the works of Mazurkiewicz [Maz], Milner [Mil], Pratt [Pra] and many others. The Mazurkiewicz trace theory requests for specifying the dependency relation, which makes such difference explicit. If in some state the sequences ab and ba are executable, then if a and b are independent, then bo...

Helngi11cering and reorganJzinx nrw product processe.t (1nd structure.v is an unending endeavor, . . . Robert G. Cooper and Ellta J. Kleinschmidt (199S). "Bendunarldng the Finn's Critical Success factO<S in New Product Development" Th• world con dmlbtl•ss nevor In wt/I known by theory: proctict ,. obS()/wttly ntct!nary; bid "11Ttly ii is of grrat iae ta a yowng man. bt· fort hu •ts owt far that...

1. Greenwald MJ, Weiss A, Oesterle CS, Friendly DS. Traumatic retinoschisis in battered babies. Ophthalmology. 1986;93:618-625. 2. Massicotte SJ, Folberg R, Torczynski E, Gilliland MGF, Luckenbach MW. Vitreoretinal traction and perimacular retinal folds in the eyes of deliberately traumatized children. Ophthalmology. 1991;98:1124-1127. 3. Lantz PE, Sinal SH, Stanton CA, Weaver RG Jr. Perimacula...

Automatic beat tracking is challenging task, especially for audio music with time-varying meters. This study proposes a dynamic programming approach with positional weighting window to handle beat tracking with time-varying meters. In particular, the tempo curve is the reference to obtain correct beat positions. The weighting window is used to adapt bandwidth of tempo which reciprocal represent...