Background: Candida species are among the most common causes of opportunistic fungal diseases. Among Candida species, Candida albicans is responsible for most infections. Having many strains, C. albicans is very polymorph. C. dubliniensis is very similar to albicans species both morphologically and physiologically. For an infection to occur, cell wall proteins play an important role as they en...

Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling PBMCs exposed to species causing these infections, we found a core host response healthy individuals that may govern effective clearance: it consists 156 transcripts, involving canonical non-canonical immune pathways. Systemat...

The phytochemical and pharmacological studies of leaf, bark and fruit extracts of Samadera indica were carried out on aqueous and methanolic extracts, obtained by soxhlet technique. The qualitative tests showed the presence of carbohydrates, proteins, phenolics, alkaloids, saponins, flavonoids, tannins and resins, whereas quantitative estimations of carbohydrate, protein, phenolics and tannins ...

BACKGROUND AND OBJECTIVES The Gracilaria (G.) sp are widely used in the traditional medicine in Malaysia. The methanol extract of Gracilaria changii B.M. Xia & I.A. Abbott (Gracilariaciae) was evaluated for antiyeast activity against Candida albicans (Berkhout). MATERIALS AND METHODS The antiyeast activities were studied by using disc diffusion method and broth dilution method. The effect of ...

In vitro studies have indicated the importance of Toll-like receptor (TLR) signaling in response to the fungal pathogens Candida albicans and Aspergillus fumigatus. However, the functional consequences of the complex interplay between fungal morphogenesis and TLR signaling in vivo remain largely undefined. In this study we evaluate the impact of the IL-1R/TLR/myeloid differentiation primary res...

Back ground: Candida albicans is a member of the normal human microflora. C. albicans cell wall is composed of several protein and carbohydrate components which have been shown to play a crucial role in C. albicans interaction with the host immune system. Major components of C. albican cell wall are carbohydrates such as mannans, β glucans and chitins, and proteins that partially modulate the h...

Candidiasis are life-threatening systemic fungal diseases, especially of gastro intestinal track, skin and mucous membranes lining various body cavities like the nostrils, the mouth, the lips, the eyelids, the ears or the genital area. Due to increasing resistance of candidiasis to existing drugs, it is very important to look for new strategies helping the treatment of such fungal diseases. One...

chemodiversity in plants provides sources of great value which might be helpful for finding new leads in drug discovery programs. fabaceae as the third largest family of flowering plants was chosen to investigate its possible antifungal activity. in order to increase the effectiveness of the result, molecular similarity methods and chemical data were used. twelve plants were selected from fabac...

BACKGROUND Candidiasis is one of the most prevalent and important opportunistic fungal infections of the oral cavity caused by Candida yeast species like Candida albicans, C. glabrata, and C. krusei. In addition, several bacteria can cause oral infections. The inhibition of microbial biofilm is the best way to prevent oral infections. OBJECTIVES The aim of the present study is to evaluate the...

background & aim: in recent years using from plant product has been considered wildly as main factor for preventing pathogenic diseases cassed by attacking viruses, bacteria, fungi and parasites. there are some funguses which could be the factors for affliction of some diseases in human, plants and animals. plant extracts are those which could act and be used as preventing from these diseas...