Small nuclear RNA and associated lupus autoantigens activate B cells and dendritic cells via Toll-like receptor-7 (TLR-7); therefore, TLR-7 may represent a potential therapeutic target in lupus. MRL lpr mice were administered an injection of either saline or synthetic oligodeoxynucleotides with immunoregulatory sequences (IRS) that specifically block signaling via TLR-7 (IRS 661) or via TLR-7 a...

OBJECTIVES A recent survey of laboratories in Kampala, Uganda, demonstrated that only 0.3% of laboratories (3/954) met international quality standards. To benchmark laboratory quality throughout the rest of sub-Saharan Africa (SSA), we compiled a list of SSA laboratories meeting international quality standards. METHODS Accrediting bodies were queried via online registries or direct communicat...

The present study investigated the effects of a new bradykinin B(1) receptor antagonist, R-954, on the development of Ehrlich ascitic tumor (EAT) induced by the intraperitoneal inoculation of EAT cells in mice and the formation of a solid tumor by the subcutaneous injection of the cells in rat paw. The development of the tumor was associated with an increase in mouse total cell counts in bone m...

JERRY SWAN1, GABRIELA OCHOA1, GRAHAM KENDALL1, MARTIN EDJVET2 1Automated Scheduling, Optimisation and Planning (ASAP) Research Group, School of Computer Science and Information Technology, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham NG8 1BB, UK. Tel.: (+44) (0)115 846 6504, Fax: +44 (0)115 846 7877. 2School of Mathematical Sciences, University of Nottingham, University P...

Propranolol Muscular Subaortic Stenosis: Prevention of Outflow Obstruction with Online ISSN: 1524-4539 Copyright © 1968 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Dallas, TX 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, 1968, 38:846-858 Circulation http://circ.ahajournals.org/content/38/5/846 services, is located on the Wo...

INTRODUCTION The aim of this study was to investigate whether serum biomarker levels of C2C, C1,2C, CS846, and CPII can predict the long-term course of disease activity and radiographic progression early in the disease course of rheumatoid arthritis (RA). METHODS In patients in the CAMERA trial, levels of biomarkers were evaluated at baseline and after 1 year of treatment. Relations of (chang...

Objective: In this study, it was aimed to determine the level of knowledge medical students about coronavirus disease 2019
 (COVID-19), investigate frequency depression, anxiety, stress symptoms and related factors.
 Materials Methods: The study is a cross-sectional conducted with 904 volunteer students. Data were collected
 an online questionnaire, including sociodemographic cha...

http://dx.doi.org/10.1016/j.foreco.2014.09.002 0378-1127/ 2014 Elsevier B.V. All rights reserved. ⇑ Corresponding author. Tel.: +1 352 846 0851; fax: +1 352 846 1277. E-mail address: [email protected] (C.A. Gonzalez-Benecke). Carlos A. Gonzalez-Benecke a,⇑, Salvador A. Gezan , Timothy J. Albaugh , H. Lee Allen , Harold E. Burkhart , Thomas R. Fox , Eric J. Jokela , Chris A. Maier , Timothy A. Ma...