The two mol-ecules in the asymmetric unit of the title compound, C(9)H(6)ClNO(3), are nearly planar, with r.m.s. deviations of 0.034 and 0.037 Å. The crystal structure is stabilized by two weak inter-molecular N-H⋯O inter-actions.

Reactions of 4-hydroxycoumarin 1 with heterocyclic aldehydes 2-4 led to bis-4-hydroxycoumarin derivatives 5-7 under microwave irradiation as well the classical heating. The subsequent reactions products are described. 4,4’-Epoxydicoumarins 8, 9 were prepared by reaction in acetic acid / p-toluenesulfonic medium. Compound 10 was 5 anhydride presence sodium acetate. Dioxocine-1,15-dione 11 6 dich...

Treatment of 3-formylacetylacetone with the amines benzylamine, tert -butylamine and ( S )-methylbenzylamine led to formation corresponding Schiff bases 3-[(benzylamino)methylidene]pentane-2,4-dione, C 13 H 15 NO 2 1 ), 3-[( -butylamino)methylidene]pentan-2,4-dione, 10 17 ) 3-{[( )-benzyl(methyl)amino]methylidene}pentane-2,4-dione, 14 3 ). The molecules all three compounds exist as enamine taut...

Two polypyridyl copper(II) complexes, [Cu(phen)(phen-dione)Cl]Cl (1) and [Cu(bpy) (phen-dione)Cl]Cl (2), (where Phen =1,10-phenanthroline, bpy =2,2'-bipyridine and Phen-dione = 1,10-phenanthroline-5,6-dione), were used as efficient catalysts for the oxidation of benzyl alcohol to benzaldehyde. The effects of various parameters such as reaction temperature, reaction time, etc. were studied. The ...

Metabolic activation of the proximate carcinogen benzo[a]pyrene-7,8-trans-dihydrodiol (B[a]P-7,8-trans-dihydrodiol) by aldo-keto reductases (AKRs) leads to B[a]P-7,8-dione that is both electrophilic and redox-active. B[a]P-7,8-dione generates reactive oxygen species resulting in oxidative DNA damage in human lung cells. However, information on the formation of stable B[a]P-7,8-dione-DNA adducts...

Recent studies from this laboratory have demonstrated that 19-nor-deoxycorticosterone, a potent mineralocorticoid, has been excreted in excess in the urine of young spontaneously hypertensive rats (SHR). Although urinary 19-nor-deoxycorticosterone levels decline before the onset of hypertension, preliminary evidence suggests that 19-nor-deoxycorticosterone is further oxygenated to other steroid...

Colorectal cancer (CRC) is a disease with high incidence and mortality, constituting the fourth most common cause of death from cancer worldwide. Naphthoquinones are attractive compounds due to their biological and structural properties. In this work, 36 naphthoquinone derivatives were synthesized and their activity evaluated against HT-29 cells. Overall, high to moderate anti-proliferative act...

Introduction: Dione (1124 km in diameter) is a mid-sized icy moon of Saturn which shows a wide range in tectonic features across its surface revealing an intense geologic history. With the two highly evolved satellites Enceladus und Titan, Dione forms a set of three satellites whose surfaces have been shaped by tectonic activity on a global, not only on regional scale. Tectonic forms on Dione w...

A series of twenty new N-[(4-arylpiperazin-1-yl)-propyl]-2-aza-spiro[4.4]nonane- and [4.5]decane-1,3-dione derivatives were synthesized and their anticonvulsant activity was evaluated in maximal electroshock (MES) and sc pentertazole (sc PTZ) tests. Their neurotoxicity was examined as well. Although no antiseizure properties of the investigated compounds were found in the MES model, eight of th...