The protease from Chromohalobacter japonicus BK-AB18 was produced by growing bacteria in a LB medium containing 5% casein and NaCl. crude partially purified three levels of ammonium sulfate concentration (ranges 0–70%, 70–75% 75–80%) the highest specific activity exhibited range 75–80%. enzyme has relative molecular weight 65 kDa. this fraction had following optimum conditions: 7.5% NaCl, pH 9....

Sunday 2/13/05 15 24 60 29 64 24 –6.7% 16.7% Monday 2/14/05 18 65 80 78 78 88 2.5% –12.8% Tuesday 2/15/05 17 75 80 90 78 104 2.5% –15.6% Wednesday 2/16/05 15 82 60 98 68 112 –13.3% –13.8% Thursday 2/17/05 18 74 80 89 90 88 –12.5% 0.9% Friday 2/18/05 14 89 60 107 56 100 6.7% 6.4% Saturday 2/19/05 10 40 48 48 48 48 0.0% 0.0% Sunday 2/20/05 15 26 60 31 65 24 –8.3% 23.1% Monday 2/21/05 19 78 80 94 ...

OBJECTIVE Anticoagulation is a challenge for the prophylaxis of thromboembolic events in elderly patients with chronic atrial fibrillation. Stable anticoagulation is defined as the time within >70% of the therapeutic range. However, the dosage required to achieve stable anticoagulation remains unknown. The aim of this study was to analyze the warfarin dose necessary for the maintenance of stabl...