Yunkyong Hyon, null Marcos, Thomas R. Powers, Roman Stocker and Henry C. Fu Journal of Fluid Mechanics / Volume 705 / August 2012, pp 58 ­ 76 DOI: 10.1017/jfm.2012.217, Published online: 15 June 2012 Link to this article: http://journals.cambridge.org/abstract_S0022112012002170 How to cite this article: Yunkyong Hyon, null Marcos, Thomas R. Powers, Roman Stocker and Henry C. Fu (2012). The wigg...

BACKGROUND Abnormal activity of STAT3 is associated with a number of human malignancies. Hsp90 plays a central role in stabilizing newly synthesized proteins and participates in maintaining the functional competency of a number of signaling transducers involved in cell growth, survival and oncogenesis, such as STAT3. Hsp90 interacts with STAT3 and stabilizes Tyr-phosphorylated STAT3. It has bee...

Despite the key role that pattern recognition receptors (PRRs) play in regulating immunity in plants and animals, the mechanism of activation of the associated non-arginine-aspartate (non-RD) kinases is unknown. The rice PRR XA21 recognizes the pathogen-associated molecular pattern, Ax21 (activator of XA21-mediated immunity). Here we show that the XA21 juxtamembrane (JM) domain is required for ...

The incidence of pyogenic arthritis is less than that of transient synovitis and varies substantially (from 1/100,000 to 37/100,000 children) depending on the population studied. Although pyogenic arthritis occurs in all age groups, the peak incidence of disease is in children under 3 years of age. A history of trauma temporally related to the onset of arthritis caused by Staphylococcus aureus ...

Rodent animal models have been widely used for studying neurologic and toxicological events associated with cocaine abuse. It is known that the mouse is more susceptible to cocaine-induced hepatotoxicity (CIH) than the rat. However, the causes behind this species-dependent sensitivity to cocaine have not been elucidated. In this study, cocaine metabolism in the mouse and rat was characterized t...

[This corrects the article on p. 705 in vol. 25.].

Acute otitis media, inflammation of the middle ear, is the most common bacterial infection in children and, as a consequence, is the most common reason for antimicrobial prescription to this age group. There is currently no effective vaccine for the principal pathogen involved, non-typeable Haemophilus influenzae (NTHi). The most frequently used and widely accepted experimental animal model of ...

Antiviral Activity of Favipiravir (T-705) Against Lethal Rift Valley Fever Virus Infection in Hamsters

Title: Improving the role and contribution of pharmacokinetic analyses in antimalarial drug 1 clinical trials 2 3 4 Running Title: Pharmacokinetics in antimalarial drug trials 5 6 Katherine Kay, Eva Maria Hodel and Ian M. Hastings 7 8 Authors affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, 9 UK 10 11 Corresponding author. Mailing address: Liverpool School ...