benign prostatic hyperplasia (bph) is a non-malignant enlargement of the prostate gland. itis a leading disorder of the elderly male population. excessive production of dihydrotestosteronehas been implicated in this pathological condition. steroidal 5α-reductase is a membrane boundnadph dependent enzyme which is responsible for the conversion of testosterone (t) todihydrotestosterone (dht). the...

In order to produce a reporter gene assay for androgenic chemicals, a constitutive expression vector coding for the human androgen receptor and a reporter construct containing the firefly luciferase coding sequence under transcriptional control of the androgen responsive MMTV promoter were cotransfected into the androgen-insensitive human PC-3 prostate carcinoma cell line and stable transfectan...

The medial preoptic area (MPOA), bed nucleus of the stria terminalis (BNST), and medial amygdaloid nucleus (Me) are essential for male sexual behavior in the Syrian hamster. These nuclei received chemosensory stimuli and gonadal steroid signals, both of which are required for mating behavior. The objective of this study was to compare the distribution of androgen- and estrogen-concentrating neu...

Even though they were introduced only a few years ago, peer-to-peer (P2P) filesharing systems are now one of the most popular Internet applications and have become a major source of Internet traffic. Thus, it is extremely important that these systems be scalable. Unfortunately, the initial designs for P2P systems have significant scaling problems; for example, Napster has a centralized director...

UNLABELLED To clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on arteriolar biomechanics in a rat model and the possible modulatory role of vitamin D3. METHODS AND RESULTS The PCOS model was induced in female Wistar rats by ten-weeks DHT treatment. Arteriolar biomechanics was tested in arterioles by pressure arteriography in control as well as DHT- an...

Accurate measurement of sex hormone binding globulin (SHBG) by 5 alpha-dihydrotestosterone (DHT) binding assays requires the establishment of acceptable upper and lower limits of labelled DHT binding and the use of optimal quantities of radioinert DHT to displace labelled DHT. A computer assisted binding assay for SHBG is described in which upper and lower binding limits are derived mathematica...

This paper presents two Fortran programs that calculate the mixed radix discrete Hartley transform (DHT) using a general odd length p-point DHT module and several short length Winograd DHT (WDHT) modules. Each program has its own advantages such as simplicity for implementation or minimum arithmetic complexity. New efficient radix-3, odd radix-p FHT algorithms and short WDHT modules have been d...

ca1 region of hippocampus has an important role in learning and memory. previous reports have shown that androgens like testosterone and its metabolites are present in high concentration in ca1 region of hippocampus. androgen receptors have also high density in this region. therefore, it is suggested that neurohormones in ca1 have an important role in learning and memory. it is likely that test...

     CA1 region of hippocampus has an important role in learning and memory. Previous reports have shown that androgens like testosterone and its metabolites are present in high concentration in CA1 region of hippocampus. Androgen receptors have also high density in this region. Therefore, it is suggested that neurohormones in CA1 have an important role in learning and memory. It is likely that...

BACKGROUND Dihydrotestosterone (DHT) induces androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. We previously demonstrated how changes in the microRNA (miRNA) expression profile influenced DHT-mediated cell death, cell cycle arrest, cell viability, the generation of reactive oxygen species (ROS), and senescence. Protective effects against DHT have not, how...