Irosustat is a novel steroid sulfatase inhibitor for hormone-dependent cancer therapy. Its structure is a tricyclic coumarin-based sulfamate that undergoes desulfamoylation in aqueous solution, yielding the sulfamoyl-free derivative, 667-coumarin. The aim of the present work was to study the in vitro metabolism of irosustat, including its metabolic profile in liver microsomes and hepatocytes, t...

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In its dormant state, the membrane cytoskeletal linker protein ezrin takes on a NH(2) terminal-to-COOH terminal (N-C) binding conformation. In vitro evidence suggests that eliminating the N-C binding conformation by Thr(567) phosphorylation leads to ezrin activation. Here, we found for resting gastric parietal cells that the levels of ezrin phosphorylation on Thr(567) are low and can be increas...

This paper describes a new algorithm for computing linear generators (vector generating polynomials) for matrix sequences, running in subquadratic time. This algorithm applies in particular to the sequential stage of Coppersmith’s block Wiedemann algorithm. Experiments showed that our method can be substituted in place of the quadratic one proposed by Coppersmith, yielding important speedups ev...

Unheard Voices A. G. Graham, F.R.C.S.ED.; C. G. Elliott, B.M . .................................................. 563 Hypocalcaemia and Breast-feeding D. J. Pearce, M.B............................... 563 Ergometrine D. D. Moir, F.F.A.R.C.S......................... 563 Errant Genes R. Duguid, M.SC . ................ 563 Recurrent Virus Meningitis E. Klemola, M.D.....................................

567-meshes are a new type of closed and 2-manifold triangular meshes introduced by Aghdaii et al. in 2012 [1]. Vertices with valence less than 5 or greater than 7 are problematic for many mesh processing tasks such as edge collapse or surface subdivision. However, vertices with valence equal to 6 everywhere is most often impossible due to either surface topology or surface feature preservation,...

Troubleshooting misconfigurations of modern applications is difficult due to their large and complex state. Snitch is a prototype tool that assists human troubleshooters by finding relationships between application state and subsequent faults. It correlates configuration state and application errors across many machines and users, and across long periods of time. Snitch aids the human expert in...