Significant progresses have been made in genetic research in MDS. Through RNA interference technology, knockdown of RPS14 recapitulated the pathological process of decreased erythropoiesis [1]. Transgenic expression of RPS14 in 5qMDS cells rescued the phenotype of insufficient erythropoiesis. This strongly suggests that haploinsufficiency of RPS14 is one of the molecular mechanisms in the patho...

BACKGROUND CXCR4 chemokine receptor is constitutively expressed on normal and malignant B lymphocytes derived from patients with B-cell lymphoproliferative disorders and has a significant role in cell migration to lymph nodes and bone marrow. Non-Hodgkin's lymphomas (NHL) constitute a heterogeneous group of lymphoproliferative diseases, which can localize not only to lymph nodes, but also can m...

5146 Background: Sunitinib (Su) has been approved in metastatic clear cell carcinoma due to high objective response rates (ORR) and a prolonged progression-free survival (PFS). Subgroups analysis of previous studies hypothesized that Su may be active in PRCC. Type I and II papillary RCC pts have a poor prognosis, with limited effective agents. METHODS SUPAP is a single-arm prospective study u...

BACKGROUND Post-traumatic syringomyelia (PTS) is a common disease after spinal cord injury (SCI). The present study was performed to evaluate the advantages of diffusion tensor imaging (DTI) in estimating SCI and prognosing PTS in SCI rats. MATERIAL AND METHODS Forty rats were divided into 3 groups based on the extent of the individual SCI and PTS: a control group (n=10), a PTS group (n=8), and...

OBJECTIVE To retrospectively evaluate the role of the various imaging techniques in the study of the sternocostoclavicular joint, in patients with spondyloarthropathies and other rheumatic conditions and to assess potential pitfalls in the radiological diagnosis. SUBJECTS AND METHODS Thirty patients, 11 male and 19 female, mean age 45 years, with involvement of the sternocostoclavicular joint...

RATIONALE No large studies till date are available from India on post-traumatic seizures (PTS). METHODS This is a prospective observational study of 520 patients with traumatic brain injury (TBI) (July 2007-2008). Patients admitted after 24h of injury, with Glasgow coma scale (GCS)<or=4 were excluded. RESULTS At a median follow-up of 386 days, 59 (11.4%) patients developed PTS. Incidence of...

Partial transmit sequence (PTS) is an attractive scheme for peak-to-average power ratio (PAPR) reduction in orthogonal frequency division multiplexing (OFDM) systems, but its high computational complexity to find optimum phase factors is the main drawback. In this paper, we propose PTS based on an artificial bee colony (ABC) algorithm (ABC-PTS) for reducing the computational complexity of the P...

OBJECTIVE We previously reported the results achieved in detecting sentinel lymph nodes (SLN). We applied the molecular techniques (RT-PCR) to improve the detection of micrometastasis in order to evaluate an improvement of staging in early non-small cell lung cancer (NSCLC) patients (pts). METHODS This study was carried out on 22 consecutive NSCLC pts with stage I disease. A dose of 37MBq (1 ...

Introduction Cryoballoon ablation (CB) has proven effective to treatment of patients (pts) with atrial fibrillation (AF). However, the isolated efficacy of CB to treat pts with long-standing persistent atrial fibrillation (LSPAF) is less know. We analyzed the acute results and the long-term follow-up of our pts suffering LSPAF and initially treated with CB. Methods A cohort of 44 pts, 37 male (...

Para-toluenesulfonamide (PTS) has been implicated with anticancer effects against a variety of tumors. In the present study, we investigated the inhibitory effects of PTS on tongue squamous cell carcinoma (Tca-8113) and explored the lysosomal and mitochondrial changes after PTS treatment in vitro. High-performance liquid chromatography showed that PTS selectively accumulated in Tca-8113 cells w...