Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in embryos. The ALB1 enhancer DNA sequence is reportedly incorporated into nucleosomes in cells, although the nucleosome structure containing the tar...

Geminivirus infectivity is thought to depend on interactions between the virus replication-associated proteins Rep or RepA and host retinoblastoma-related proteins (pRBR), which control cell-cycle progression. It was determined that the substitution of two amino acids in the Maize streak virus (MSV) RepA pRBR-interaction motif (LLCNE to LLCLK) abolished detectable RepA-pRBR interaction in yeast...

BACKGROUND Colorectal cancer (CRC) is a major cause of death worldwide. Sensitive, non-invasive diagnostic screen methods are urgently needed to improve its survival rates. Stable circulating microRNA offers unique opportunities for the early diagnosis of several diseases, including cancers. Our aim has been to find new plasma miRNAs that can be used as biomarkers for the detection of CRC. ME...

Chronic hyperleptinemia results in the development of hypertension in pregnant rats 1 2 3 4 Ana C. Palei, Frank T. Spradley and Joey P. Granger 5 6 Department of Physiology and Biophysics and Cardiovascular-Renal Research Center, 7 University of Mississippi Medical Center – 2500 North State Street, Jackson/MS, 39216 8 9 10 11 Running head: Hyperleptinemia increases blood pressure in pregnant ra...

A new fourth order compact formulation for the steady 2-D incompressible Navier-Stokes equations is presented. The formulation is in the same form of the Navier-Stokes equations such that any numerical method that solve the Navier-Stokes equations can easily be applied to this fourth order compact formulation. In particular in this work the formulation is solved with an efficient numerical meth...

1Dept. of Physics, CSUSB, 5500 University Parkway, San Bernardino, CA 92407 2Johns Hopkins University/Applied Physics Laboratory, 11100 Johns Hopkins Rd, Laurel, MD 20723 3The Observatories of the Carnegie Institute of Washington, Las Campanas Observatory, Colina El Pino, Casilla 601, La Serena, Chile 4Planetary Astronomy Group, Astromaterials Research and Exploration Science, NASA Johnson Spac...

Abstract We show that the number of isomorphism classes left braces order 64 with additive group isomorphic to $$C_2\times C_2\times C_4\times C_4$$ C 2 × 4 is $$10{,}326{,}821$$ 10 ,</mml...

Article history: Received on: 10/04/2014 Revised on: 06/05/2014 Accepted on: 19/05/2014 Available online: 27/05/2014 In this study, Pediococcus pentosaceus VTCC-B-601 was investigated and characterized for bacteriocin production. The antimicrobial activities were produced strongly at the late exponential phase (5x10 CFU/ml), corresponding to the activity of cephalosporin (13.3μg/ml) against Sal...

The recent decision in Alexander v. Sandoval has seriously limited the available opportunities for minorities to argue their claims for environmental justice. Prior to Sandoval, plaintiffs alleging disparate impact as a result of the policies implemented by a federally funded agency met with moderate success under Title VI section 602. After Sandoval, however, the chances of success in private ...