The guanine analog, 6-thioguanine (4), has been found to be a potent inhibitor of animal neoplasms (2) and human leukemia (5) when administered alone, and even more potent when used in com bination with the inhibitor of de novo purine syn thesis, azaserine (10, 12). We have developed a thioguanine-resistant subline of the Ehrlich ascites carcinoma. Using this as a tool, we have studied the meta...

The effects of 4-aminopyrazolo(3,4-d)pyrimidine (APP), alone or in combination with azaserine, thioguanine, and 6-mercaptopurine, have been tested in Ehrlich ascites carcinoma, Sarcoma 180 ascites, 6C3HED ascites lymphosarcoma, Mecca ascites lymphosarcoma, and TAS ascites carcinoma. The Ehrlich ascites carcinoma is the only tumor of this series which responds to APP. Several combinations of APP...

AIM We evaluated the effect of coadministration of sulphasalazine, mesalamine, and balsalazide on the pharmacokinetics and pharmacodynamics of azathioprine and 6-mercaptopurine. METHODS Thirty four patients with Crohn's disease receiving azathioprine or 6-mercaptopurine were enrolled in an eight week non-randomised parallel group drug interaction study and treated with mesalamine 4 g/day, sul...