STUDY OBJECTIVES To assess the efficacy and safety of continuous subcutaneous infusion of treprostinil, a stable prostacyclin analogue, for treating pulmonary arterial hypertension (PAH) in patients with connective tissue disease (CTD). DESIGN Two multicenter, randomized, double-blind, placebo-controlled, prospective trials of treprostinil vs placebo in 470 patients with PAH. PATIENTS A sub...

BACKGROUND Pulmonary arterial hypertension (PAH) is a life-threatening disease for which both continuous IV epoprostenol and continuous subcutaneous treprostinil have proven effective. With continuous IV treprostinil having potential advantages over both of the above therapies, we investigated the safety and efficacy of this regimen in patients with PAH. METHODS We conducted a 12-week, prospe...

BACKGROUND Physical disability in multiple sclerosis (MS) is frequently characterized by impaired ambulation. Although walking tests have been successfully employed to assess walking ability in MS patients, data analytic procedures have predominantly relied on result-oriented parameters (e.g. total distance covered during a given amount of time), whereas process-oriented, dynamic walking patter...

OBJECTIVE We investigated the association between full breast-feeding up to 6 months as well as partial breast-feeding after 6 months and maternal weight retention at 6, 18 and 36 months after delivery in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. DESIGN Cohort study. Information on exposure and outcome was collected by questionn...

The present study aimed to estimate heritability, genetic and phenotypic correlations between body weight and body measurement traits in Iranian Makuei sheep. The used data were collected from 1989 to 2012 at Makuei Sheep Breeding Station in Maku (West Azarbayjan province). The data included body weight and five body measurement traits (body length (BL), heart girth (HG), withers height (WH), r...