1. Abstract 2. Introduction 3. Discussion 3.1. Integrins and Osteoclasts 3.1.1. Mechanism of Osteoclastic Bone Resorption 3.1.2. Integrin alphavbeta3 is Involved in Regulating Osteoclastic Bone Resorption 3.2. PYK2 in Osteoclasts 3.2.1. Functional Expression of PYK2 in Osteoclasts 3.2.2. PYK2 in Integrin alphavbeta3-mediated Signaling in Osteoclasts 3.3. FAK in Osteoclasts 3.3.1. Functional Exp...

We explored the hypothesis that the chemotactic migration of carcinoma cells that assemble hemidesmosomes involves the activation of a signaling pathway that releases the a 6 b 4 integrin from these stable adhesion complexes and promotes its association with F-actin in cell protrusions enabling it to function in migration. Squamous carcinoma-derived A431 cells were used because they express a 6...

Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, capable inhibiting cell adhesion to extracellular matrix (ECM). This functional site usually buried within molecular structure FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 induce a change in β1-integrin active inactive form, c...

background: endometrial integrin expression changes might be a reason for implantation failure in polycystic ovarian syndromes (pcos). objective: assessment of integrin genes and proteins expression upon endometrium in the pcos experimental mouse model was the main goal of this study. materials and methods: 30 nmri female mice were equally divided into control, experimental (pcos; received estr...

The integrin alpha v beta 6 is only expressed in epithelial cells. In healthy adult epithelia, this receptor is barely detectable, but expression is rapidly induced following epithelial injury. Mice homozygous for a null mutation in the gene encoding the beta 6 subunit had juvenile baldness associated with infiltration of macrophages into the skin, and accumulated activated lymphocytes around c...

Background: Integrins are transmembrane mechanosensitive proteins that negatively contribute to the pathogenesis of different types chronic liver disease and can activate focal adhesion kinase (FAK). Objectives: This study aimed determine hepatic integrin β1 FAK mRNA as well transcriptional coactivator with PDZ-binding motif (TAZ) protein expressions in cirrhotic patients simple steatosis. Meth...

Mast cells, critical mediators of inflammation and anaphylaxis, are poised as one of the first lines of defense against external assault. Mast cells release several classes of preformed and de novo synthesized mediators. Cross-linking of the high-affinity FcεRI results in degranulation and the release of preformed, proinflammatory mediators including histamine and serotonin. We previously demon...

the interaction between molecular biology and embryology made an extensive progress in the research on gametogenesis, fertilization and early embryogenesis in mice. in this article, molecules involving in meiotic maturation and apoptosis of oocytes, sperm-oocyte interactions and early cleavage of fertilized embryos in mice are described including our recent following experiments. 1) phosphatidy...

introduction: the implantation is a complex procedure that involves many molecules. one of these molecules is integrin specially &alphav;&beta3; which serves as receptor for components of extra cellular matrix to act as bridging molecules between the blastocyst and the endometrial surface during the implantation process. by blocking &alphav;&beta3; interactions, the implantation can be impaired...

background: it has been hypothesized that blastocyst integrin expression changes can affect the spontaneous miscarriage in polycystic ovarian syndromes (pcos). objective: in this study, the profile of integrin genes and proteins was investigated on blastocyst of the pcos experimental mouse model. materials and methods: 30 nmri female mice were equally divided into 3 groups: control, experimenta...