W. S. H am am a Chemistry D epartm ent, Faculty of Science, M ansoura University, M ansoura, Egypt R eprint requests to Dr. W. S. H am am a. E-mail: Sinfac@ mum.mans.eun.eg Z. Naturforsch. 55b, 443-447 (2000); received January 25, 2000 6-Am inouracil, M annich Reaction, Pyrimido[4,5-d]pyrim idine The reaction of 6-am inouracil 1 with form aldehyde and secondary amines in ethanol at room tem per...

Liquid–liquid extraction of carbonate and mixed peroxo-carbonate compounds U(VI) Am(III) from Na2CO3 aqueous solutions by methyltrioctylammonium in toluene has been studied. The main patterns effect extractant, Na2CO3, H2O2 concentration on distribution separation have established. Using slope analysis UV–vis spectroscopy, the compositions extractable are established as (R4N)4[UO2(CO3)3], (R4N)...

Objective(s): Inhaled aerocontaminants are removed from the lungs by pulmonary mucociliary transport (MCT) as an important defense mechanism. This study was undertaken to investigate the influence of the surface potential of magnetic nanoparticles (MNPs) on the MCT in murine lungs by use of magnetic particle imaging (MPI).Materials and Methods: Three kinds of MNPs (carboxymethyl dextran m...

The peptide AM (adrenomedullin) is stimulated by hypoxia through HIF-1 (hypoxia-inducible factor-1). The majority of human CC-RCCs (clear cell renal cell carcinomas) display mutations in the tumour suppressor protein von Hippel-Lindau, which leads to constitutively elevated HIF-1. We hypothesized that AM is increased in CC-RCC tumours and that AM is a plasma biomarker for CC-RCC. Tumours and no...

PURPOSE To evaluate in suspected and glaucomatous patients the correlation between central corneal thickness (CCT) and intraocular pressure (IOP), measured during the daily curve of intraocular pressure (DCPo), including CCT and IOP measurements in bed at 6 am. The ocular axial length was also compared. METHODS 114 eyes from 73 patients, 30 eyes suspected of glaucoma (group I) and 84 eyes wit...

The concentrations of morphine and 6-acetylmorphine (6-AM) in urine, cerebrospinal fluid (CSF), and vitreous humor (VH) and the morphine concentrations in blood were determined by gas chromatography-mass spectrometry for 29 fatalities after abuse of heroin either alone or in combination with alcohol and other drugs. 6-AM was found above a quantitation limit of 1 ng/mL in urine in 89% of the cas...

Adrenomedullin (AM) is secreted from cultured cardiac myocytes. In this study, we examined whether mechanical stretching stimulates AM production in cardiac myocytes, and if so, whether angiotensin II (Ang II) is involved in that mechanism. Neonatal rat cardiac myocytes cultured in serum-free medium were stretched 10% or 20% on flexible silicone rubber culture dishes, and AM mRNA expression was...

Adrenomedullin (AM), a potent vasodilator peptide, exists in the cardiac ventricle; however, the role of AM in the ventricular tissue remains unknown. In the present study, we investigated the production and secretion of AM in cultured neonatal rat cardiomyocytes, and we examined the effect of AM on de novo protein synthesis in these cells by measuring [14C]phenylalanine incorporation. The card...

2-Am ino-5-nitro-6-(r-D -ribityl)am ino-4(3H )-pyrim idinone (6a) was converted to the dimethoxytrityl derivative, which was subsequently acetylated. The trityl residue was then rem oved, and the compound was phosphorylated by the cyanoethyl method. Rem oval of the protecting groups yielded 2-am ino-5-nitro-6-(l'-D-ribityl)am inopyrim idinone 5'-phosphate (11a). Catalytic hy­ drogenation yielde...